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淋球菌多重耐药基因系统研究进展 被引量：2

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摘要 淋病是目前最常见的性病之一,近年来,由于抗菌药物的广泛应用,导致淋球菌耐药性不断增加。细菌在抗生素选择性压力的作用下,可保留最耐药的菌株,对大多数抗生素产生耐药。多重耐药即细菌不仅对某种亲脂性细胞毒药物耐药,而且对一大群相互之间没有关联的药物都有抵抗力。
作者 侯临平 程育春 赵艳霞
机构地区 山西省临汾市人民医院
出处 《实用医技杂志》 2011年第6期609-610,共2页 Journal of Practical Medical Techniques
关键词 淋球菌耐药性 多重耐药 基因系统 抗菌药物 选择性压力 药物耐药 抗生素 细胞毒
分类号 R379 [医药卫生—病原生物学]
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参考文献4

二级参考文献37

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共引文献6

同被引文献15

  • 1陈宏翔,涂亚庭,林能兴,黄长征,张丽霞.淋球菌多重耐药性与mtrR基因点突变的关系[J].华中科技大学学报（医学版）,2005,34(5):616-618. 被引量：8
  • 2张丽霞,涂亚庭,林能兴,黄长征,陈宏翔,陶娟,林云.淋病奈瑟菌mtrR基因启动子区的IR区碱基缺失与其耐药性关系的研究[J].中国皮肤性病学杂志,2006,20(1):1-3. 被引量：2
  • 3Veal WL, Nicholas RA, Shafer WM. Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chro-mosomally mediated penicillin resistance in Neisseria gonorrhoeae[J], Bacteriol, 2002, 184(20):5619-5624.
  • 4Eun Hee Lee, William M. Shafer. The farAB-encoded efflux pumpmediates resistance of gonococci to long-chained antibacterial fattyacids[J]. Molecular Microbiology ,1999 ,33(4) : 839-845.
  • 5Cousin SL Jr,Whittington WL, Roberts MC. Acquired macrolide re-sistance genes and the 1 bp deletion in the mtrR promoter in Neisseriagonorrhoeae [ J]. Sex Transm Dis, 2004,31(6) :353-359.
  • 6Cousin S Jr, Roberts MC, Whittington WL. Insertion of a thymine( +T) in the 13 base pair inverted repeat of the Neisseria gonorrhoeae mtrpromoter region and antibiotic susceptibility [ J]. Int J Antimicrob A-gents, 2004,23(4) :418419.
  • 7Shafer WM, Balthazar JT, Hagman KE, et al. Missense mutationsthat alter the DNA-binding domain of the mtrr protein occur frequentlyin rectal isolates of neisseria gonorrhoeae that are resistant to faecal lip-ids [J]. Microbiology, 1995,141:907-911.
  • 8Schielke S, Schmitt C, Spatz C, et al. The transcriptional repressorFarR is not involved in meningococcal fatty acid resistance mediated bythe FarAB efflux pump and dependent on lipopolysaccharide structure[J ]. Applied and environmental microbiology, 2010,76 ( 10 ):3160-3169.
  • 9Lucas CE,Hagman KE,Levin JC,et al.Importance of lipooligosaceharide structure in determining gonocoeeaal resistance to hydrophobic antimicrobial agents resulting from the mtr efflux system[J].MolMicrobiol,1995,16(5):1001-1009.
  • 10Arias CA,Murray BE.Antibiotic-resistant bugs in zhe 21st centurya clinical super-challenge[J].N Engl J Med,2009,360(5):439-443.

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实用医技杂志
2011年 第6期

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