择期PCI术前强化调脂治疗对冠脉前向血流的影响

Effect of intensive lipid-lowering therapy on coronary artery forward blood flow before PCI

目的:研究急性冠脉综合征(Acute Coronary Syndrome,ACS)患者择期经皮冠状动脉介入治疗(PCI)术前5天给予不同剂量辛伐他汀治疗后对术中冠脉前向血流的影响。方法:回顾性分析2005年6月至2010年6月确诊的ACS病人,PCI术前5天给予不同剂量辛伐他汀(标准组20 mg及强化组40 mg)各98例,研究2组患者PCI术中发生慢血流(干预血管前向血流<TIMI3级)的例数。结果:标准组PCI术中发生慢血流11例,强化组3例,比较两组患者慢血流发生率有统计学意义(P<0.05),强化组发生慢血流率为3.06%,优于标准组的11.22%。结论:ACS患者PCI术前辛伐他汀强化降脂可有效降低手术慢血流发生率,使手术更具安全性。

Objective：To study coronary artery blood flow effects with different doses of Simvastatin in patients with acute coronary symptom undergoing percutaneous coronary intervention（PCI）.Method：Retrospective analysis slow blood flow incidence during PCI in patients diagnosed ACS from June 2005 to June 2010.196 ACS patients before PCI were randomly divided into standard group（20mg/d）and intensification group（40 mg/d）.Compare slow blood flow incidence patients during PCI between the two groups.Result：Slow blood flow incidence during PCI between standard group（11 patients）and intensification group（3 patients） were significantly different（P0.05）.Slow blood flow incidence rate（11.22%） in intensification group（40 mg/d） is better than that（3.06%） in standard group（20 mg/d）.Conclusion：Slow blood flow incidence rate can be reduced in ACS patients with intensive dose Simvastatin before PCI.Intensive lowering blood fat before PCI is safe for operation.