不同妊娠期孕妇血凝四项的变化及临床意义

Clinical Meaning on Variation of Coagulation Indexes in Normal Pregnant Inducedhypertension

目的:探讨孕妇在不同妊娠期凝血酶原时间(PT)、部分活化凝血酶时间(APTT)、纤维蛋白原(Fib)和凝血酶时间(TT)四项反映凝血功能指标的变化及其临床意义。方法:PT、APTT、TT、Fib测定均为凝固法,在ACL7000全自动血凝仪上进行,试剂及定标血浆均为美国贝克曼库尔特公司产品。检测120例妊娠早期、中期、晚期和60例正常非孕妇女的PT、APTT、Fib和TT,并对检测结果进行比较。结果:妊娠中、晚期妇女与正常对照组或早期妊娠者比较,PT、APTT、TT时间明显缩短、Fib含量明显增高,差异有显著性(P<0.05或P<0.01)。结论:妊娠中、晚期由于凝血功能增强出现妊娠期高凝状态。这一妊娠期生理变化为产后快速有效止血提供了物质基础,但也是导致妊娠期血栓病形成的重要原因,并可能与多种产科疾患有关。妊娠期间监测凝血四项对预防血栓形成并指导抗凝治疗有重要的临床意义。

Objective：To evaluate the clinical signification of coagulation indexes prothrombin time（PT）,activated partial thromboplastintime（APTT）,plasma thrombin time（TT）,fibrinogen（Fib） in normal pregnancywomen induced hypertension.Methods：PT、APTT、TT、Fib were assayed using oagulation method,all the peremeters were finished by ACL7000 automated blood coagulation analyzer.Reagent come from Dade Behring Marburg GmBh.Results： PT、APTT、TT,were significantly shorter and Fbg was higher in middle and later terms pregnancy women than that in normal women controls or early terms pregnancy women（P0.05或P0.01）.Conclusion：The normal pregancy women and patients with pregnancy induced hypertension have many changes in coagulation system,showing a pregnancyrelated hypercoagulate.state existing risks of thrombotic complication.Observation of PT、APTT、TT and Fbg is necessary.