SUMO化信号途径对JNK信号通路活性的调控

The Sumoylation Pathway Modulates JNK Signaling in Drosophila

c-Jun氨基末端激酶(the c-Jun N-terminal kinase,JNK)家族是促分裂原活化蛋白激酶(MAPK)超家族成员之一.JNK信号通路对细胞生长、分化和凋亡等生物学活动都有重要作用.而SUMO化是一种重要的生物学修饰,可以调节多种细胞生理活动.最近,黄海等在Development发表文章首次将SUMO化途径与JNK信号通路通过Hipk激酶联系起来,为进一步研究SUMO化的功能及其对JNK通路的调节建立了一个新的模型.

The c-Jun N-terminal kinase, JNK, is one of the mitogen-activated protein kinase superfamily members. JNK signaling pathway plays important roles in a variety of biological activities such as cell growth, differentiation and apoptosis. Post-translational modification by the small ubiquitin-related modifier （SUMO）, termed as sumoylation, regulates multiple cellular and physiological processes. A very recent report in Development by Huang et al. establishes a link between sumoylation pathway and JNK pathway through the action of homeodomain-interacting protein kinase （Hipk）, which advances our understanding of the JNK signaling regulation in Drosophila.