Thl 7细胞与人类肿瘤的关系研究进展

Correlation between Thl7 Cells and Human Tumors

辅助性T细胞17是新发现的一种CD4^+效应T细胞亚群,具有独特的分化发育机制,在转化生长因子-β(transforminggrowth factor beta,TGF-β)、IL-6、IL-23等多种因子及特异性转录因子孤儿核受体(Orphan nuclear receptor,RORγt)的参与下,初始CD4^+细胞分化发育为Th17细胞,活化的Th17细胞通过分泌IL-17、IL-21、IL-22等细胞因子导致炎症和疾病的发生。Th17细胞在感染性疾病、自身免疫病以及移植排斥反应中发挥重要的作用,但在肿瘤免疫中的作用却知之甚少。目前已在人类多种恶性肿瘤组织及外周血中检测到Th17细胞及其细胞因子的存在,关于Th17细胞在肿瘤发生发展中的作用,究竞是促进肿瘤还是抑制肿瘤仍存在较多争议,是近年来肿瘤免疫研究的热点。Th17细胞在肿瘤中的表达及作用机制的研究,为特异性靶向Th17细胞的抗肿瘤治疗提供理论依据。

T helper17 cells （ Th17 cell ） have been recently identified as part of the CD4＋ T helper cell lineage. It has a unique mechanism of differentiation and development. With the participation of several cytokines, such as transforming growth factor beta （ TGF-β ）, interleukin 6, and interleukin 23, and the orphan nuclear receptor （ RORyt ） of specific transcription factors, the initial CD4＋ cells differentiate and develop into Thl7 cells. The activated Th17 cells can trigger inflammations and diseases by secreting the cytokines, including interleukin 17, interleukin 21, and interleukin 22. Th 17 cells play an important role in infectious diseases, autoimmune diseases and graft rejection reactions. However, the role of these cells in tumor immunity is unknown. Th17 cells and their cytokines have recently been found in several human malignancies and peripheral blood smears. Concerning the role of Th17 cells in the onset and progression of tumors, whether they facilitate or inhibit tumor growth remains controversial. Over the past few years, it has become the focus in research on tumor immunity. The studies on Th17 cell expression in tumors and its underlying mechanism can provide a theoretical basis for specific Th 17-targeted tumor therapy.