西酞普兰联合心理治疗对卒中后抑郁及认知功能的影响研究

The Effects of the Combination of Citalopram and Psychotherapy on Post-stroke Depression and Cognitive Function

目的观察西酞普兰联合心理治疗改善卒中后抑郁患者情绪和认知功能的疗效。方法将60例卒中后抑郁患者随机分为对照组和治疗组,每组各30例。两组均给予脑血管病常规治疗,治疗组同时加用西酞普兰联合心理治疗。采用汉密尔顿抑郁量表(HAMD)、简易智能精神状态检查量表(MMSE)及事件相关电位(P300)判断抗抑郁疗效及对认知功能的影响。结果治疗12周后治疗组较对照组HAMD评分显著下降,MMSE评分显著提高,P300潜伏期显著缩短,波幅显著增高。结论西酞普兰联合心理治疗可明显改善卒中后抑郁患者的抑郁情绪和认知功能。

Objective To observe the therapeutic effect of the combination of citalopram and psychotherapy for improving mood and cognitive function in post-stroke depression patients.Methods Sixty patients with post-stroke depression were randomized into treatment group（n=30） or control group（n=30）.All patients received conventional therapies for cerebrovascular diseases and those in treatment group the combination of citalopram and psychotherapy additionally.Hamilton Depression Scale（HAMD）,mini mental state examination（MMSE） and event-related potential P300（ERP P300） were used to assess the efficacy of anti-depression therapy and the effects on cognitive function.Results After 12 weeks of therapy,compared with those in control group,the score of HAMD decreased significantly and that of MMSE increased obviously in treatment group.In addition,P300 in treatment group manifested a obvious reduction in latency and a noticeable rise in wave amplitude.Conclusion The combination of citalopram and psychotherapy improves mood and cognitive function significantly in post-stroke depression patients.