间质性肺疾病患者的生活质量及其相关因素研究

Quality of Life of Patients with Interstitial Lung Disease and Related Factors

目的评价间质性肺疾病患者的生活质量,并探讨其相关因素。方法通过便利抽样选取在北京协和医院就医的103例间质性肺疾病患者,采用圣乔治呼吸问卷(SGRQ)、肺功能检测、6 min步行试验(6MWT)、医学研究会呼吸困难量表(MRC)、医院焦虑抑郁量表(HAD)测量相关变量。结果间质性肺疾病患者的SGRQ各维度评分表现为不同程度的升高,其中活动能力的均分最高,且明显高于症状(P=0.005)、对日常生活的影响(P=0.025)两个维度。SGRQ的各维度评分与用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、肺总量(TLC)、一氧化碳弥散量(DLCo)、MRC评分、6 min步行试验距离(6MWD)、焦虑及抑郁得分相关(P<0.05)。结论间质性肺疾病患者的生活质量受损,与MRC评分的相关性最好。

Objective To evaluate the quality of life（QOL） in patients with interstitial lung disease（ILD） and to identify factors that are related with the QOL.Methods By means of convenience sampling,a total of 103 patients with ILD in our hospital were enrolled.The St.George′s respiratory questionnaire（SGRQ）,medical research council scale（MRC）,pulmonary function test,6-min walk test（6MWT）,hospital anxiety and depression scale（HAD） were used to measure the relevant parameters of the patients.Results The QOL of the patients were higher across all measured domains in SGRQ.The score of activity domain was the highest,and significantly higher than the scores of symptom（P=0.005） and impact（P=0.025） domains.Lung function（FVC,FEV_1,TLC,DLCo）,MRC score,6MWD,HAD scores were all correlated with the SGRQ scores of all domains（P〈0.05）.Conclusion The QOL in ILD patients is impaired,which is in good correlation with MRC scores.