摘要
目的为了明确支气管肺泡灌洗液(BALF)中淋巴细胞和CD4+/CD8+比值在肺结节病中的诊断意义。方法选取92例经病理诊断的结节病患者,评估其临床参数,并把支气管肺泡灌洗(BAL)作为初诊评估的一部分,检测BALF中细胞类型及淋巴细胞亚群CD4+/CD8+比值。结果对于本研究的结节病患者,CD4+/CD8+比值范围为0.2～14.3,中位值3.3(均值2.5)。仅有20例(25%)结节病患者CD4+/CD8+比值>4,8例患者(10%)CD4+/CD8+比值<1,淋巴细胞增加或减少和CD4+/CD8+比值分布相似。结论经病理确诊的结节病患者BALF中CD4+/CD8+比值分布具有高度变异性。BALF中淋巴细胞亚群对于结节病的诊断敏感性较低。
Objective To identify diagnostic significance of lymphocytes and the ratio of CD＋4 to CD＋8（CD＋4/CD＋8 ratio） in bronchoalveolar lavage fluid（BALF） in sarcoidosis.Methods Clinical parameters of 92 patients confirmed with sarcoidosis were tested,and the BAL was also evaluated in the first visit.Cell types and the ratio of CD＋4/CD＋8 in BALF were tested.Results In these patients,the CD4/CD8 ratio ranged from 0.2 to 14.3,with a median value of 3.3（mean 2.5）.The CD4/CD8 ratio was greater than 4 in only 20（25%） patients.8 patients（10%） had a CD4/CD8 ratio less than 1.The distribution of CD4/CD8 ratios was similar to the increase or decrease of BAL lymphocytosis.Conclusion The CD4/CD8 ratio in bronchoalveolar lavage fluid is highly variable in biopsy-proven sarcoidosis.Bronchoalveolar lavage lymphocyte subset determination has low sensitivity for this disease.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第17期1900-1902,共3页
Chinese General Practice
