尼莫地平联合丹红注射液治疗急性脑梗死的临床研究

Clinical Research of Nimodipine Tablets Combined with Danhong Injection in Treating Acute Cerebral Infarction

目的研究尼莫地平联合丹红注射液治疗急性脑梗死的疗效及其对凝血纤溶系统的影响。方法选择急性脑梗死患者90例,随机分为两组,治疗组45例,给予尼莫地平20 mg,每日3次,丹红注射液20 ml,静脉滴注,每日1次,连续治疗12 d;对照组45例,给予血栓通注射液0.3 g,静脉滴注,每日1次,连续治疗12 d。观察治疗前后神经功能缺损评分和凝血功能。结果治疗组患者神经功能缺损评分明显下降,凝血因子Ⅱ时间(PT)及活化部分凝血因子Ⅱ时间(APTT)延长,总有效率明显高于对照组(P<0.05),未见明显不良反应。结论尼莫地平联合丹红注射液治疗急性脑梗死安全有效。

Objective To evaluate the curative effect of Nimodipine tablets combined with Danhong injection in treating acute cerebral infarction,and observe its influence on coagulation and fibrinolysis system.Methods 90 patients with acute cerebral infarction were divided randomly into 2 groups,45 cases in treatment group were administrated Nimodipine tablets（20 mg tid）and Danhong injection（20 ml,iv drip,qd）for 12 days.45 cases in control group were administrated Xueshuantong injection（0.3 g,iv drip,qd）for 12 days.To observe the neurological function deficit score,coagulation and fibrinolysis function.Results Compared with control group,in treatment group,the neurological function deficit scores lowered significantly,PT and APTT prolonged,the total effective rate increased significantly（P0.05）.Evident adverse reactions were not found in treatment group.Conclusion Nimodipine tablets combined with Danhong injection was safe and effective in treating acute cerebral infarction.