类风湿关节炎患者血清Vaspin变化及相关因素的分析

Change of serum Vaspin level and related factor in patients with rheumatoid arthritis

目的:探讨类风湿性关节炎(RA)患者血清内脏脂肪组织来源的丝氨酸蛋白酶抑制剂(Vaspin)及与相关因子的关系,阐明Vaspin在类风湿关节炎发生过程中可能的作用机制。方法:采用酶联免疫法测定RA患者血清Vaspin水平,分析了血清Vaspin水平与炎症相关指标血沉(ESR)、α1-酸性糖蛋白(AAG)、C-反应蛋白(CRP)、类风湿因子(RF)及肿瘤坏死因子α(TNF-α)等的关系。结果:RA组血清Vaspin水平明显高于对照组[(1.58±0.20)μg/L vs(0.71±0.09)μg/L](P<0.01)。RA患者活动亚组血清Vaspin水平明显高于非活动亚组[(1.98±0.15)μg/L vs(1.32±0.12)μg/L](P<0.01)。RA组和对照组中女性血清Vaspin较男性有升高趋势。RA组患者血清Vaspin水平与TNF-α及CRP呈正相关(r=0.64,P<0.01;r=0.47,P<0.05)。TNF-α是影响空腹血清Vaspin水平的独立相关因素。结论:Vaspin可能是一种与炎症反应有关的脂肪细胞因子,在RA的发生和发展中可能具有重要作用。

Objective： To investigate the change of serum Vaspin and the relationship of serum Vaspin level to related factor in patients with rheumatoid arthritis and to clarify the probable mechanism of Vaspin in rheumatoid arthritis（RA）.Methods： Serum Vaspin level in 60 patients with RA were measured by an ELISA,and the relationship of serum Vaspin level with erythrocyte sedimentation rate（ESR）,α1-acid Glycoprotein（AAG）,C-reactive protein（CRP）,rheumatoid factor（RF） and tumor necrosis factor alpha（TNF-α） were also analyzed.Results： Fasting serum Vaspin level were significantly higher in RA group than that in control group [（1.58±0.20） μg/L vs（0.71±0.09） μg/L]（P0.01）.Fasting serum Vaspin level were significantly higher in active RA subgroup than that in inactive RA subgroup [（1.98±0.15） μg/L vs（1.32±0.12） μg/L]（P0.01）.The level of Vaspin in female subjects was modestly higher than that in male subjects,but the diference is not significant.Fasting serum Vaspin level in patients with RA correlated positively with TNF-α and CRP（r=0.64,P0.01;r=0.47,P0.05）.TNF-α was the independently predictor of serum Vaspin in patients with RA.Conclusion： Vaspin is possibly a kind of adipocytokines associated with inflammatory reaction,which may contribute,in part,to the pathogenesis of rheumatoid arthritis.