胞二磷胆碱对新生儿缺氧缺血性脑病神经行为的影响分析

The neurobehavioral effect of Citicoline on hypoxic ischemic encephalopathy in neonatal

目的:探讨胞二磷胆碱对新生儿缺氧缺血性脑病神经行为的影响。方法:回顾性分析新生儿缺氧缺血性脑病患儿的临床治疗效果与神经行为影响结果,其中采用神经节苷脂治疗(对照组)32例,采用胞二磷胆碱治疗(治疗组)32例。结果:治疗组总有效率明显高于对照组,差异有统计学意义(χ2=6.235 3,P<0.05)。两组患儿在治疗前相关指标无差异。治疗后两组患儿在NABA评分、一般状态、原始反射之间的差异有统计学意义(t=7.852 1、6.235 3、6.3632,P<0.05),而主动肌张力、被动肌张力的差异无统计学意义(t=0.236 2、0.365 2,P>0.05)。结论:临床在新生儿缺氧缺血性脑病综合治疗的基础上,尽早应用胞二磷胆碱治疗,会提高治疗有效率与改善预后,可推广应用。

Objective： To investigate the neurobehavioral effect of Citicoline on hypoxic ischemic encephalopathy in neonatal.Methods： To analyae neonatal hypoxic ischemic encephalopathy and the clinical treatment of the results of neurobehavioral effect,including treated by the Oganglioside（the control group） with 32 cases,and treated by the citicoline（the treatment group） with 32 cases.Results： The total effective rate of the treatment group was significantly higher than that of the control group（χ2=6.235 3,P0.05）.The NABA valuse,capacity,performance status of the two groups had significantly difference（t=7.852 1,6.235 3,6.363 2,P0.05）,and active muscle tone,passive muscle tension of the two groups had not significantly different（t=0.236 2,0.365 2,P0.05）.Conclusion： Citicoline on hypoxic ischemic encephalopathy in neonatal will improve efficiency and the prognosis,it can be generalized.