经皮穿刺动脉导管药盒系统药物灌注治疗下肢动脉硬化闭塞症的研究

Study of percutaneous intra-arterial femoral port-catheter system for treatment on arteriosclerosis obliterans

目的:探讨经皮动脉穿刺导管药盒系统药物灌注治疗下肢动脉硬化闭塞症的临床疗效。方法:60例下肢动脉硬化闭塞症患者,随机分为治疗组、对照组,每组各30例。治疗组患者行经皮穿刺动脉药盒系统埋植术,并经动脉导管系统行前列地尔注射液、丹参注射液灌注治疗;对照组静脉滴注上述药物。14 d为1个疗程,共治疗2个疗程。治疗前后测定踝臂指数(ABI)。结果:治疗组有效28例,无效2例,总有效率为93.33%;对照组有效16例,无效14例,总有效率为53.33%;两组总有效率差异明显(P=0.000)。两组治疗前ABI比较无差异,两组治疗后ABI均较治疗前好转(均P<0.05),但治疗组明显优于对照组(P<0.01)。结论:经皮穿刺动脉动脉导管系统药物灌注治疗下肢动脉硬化闭塞症作用明显,能有效改善下肢血液循环,疗效满意。

Objective： To investigate the clinical efficacy of percutaneous intra-arterial femoral port-catheter system（PCS） for treatment on arteriosclerosis obliterans.Methods： 60 patients with arteriosclerosis obliterans were divided into treatment group and control group;the treatment group were treated by using alprostadil injection and salvia miltiorrhiza injection via PCS.The control group were treated by using the same medication by intravenous infusion.The patients were treated in 4 weeks.Ankle brachial indexs（ABI） were examined before and after treament.Results： The effective percentage of treatment group was 93.33%,the same of control group was 53.33%.There were significantly differences between treatment group and control group（P=0.000）.There were significant differences of the ABI between treatment group and control group after treatment（P0.01）.Conclusion： The technique of percutaneous intra-arterial femoral port-catheter system implatation for interventional treatment for arteriosclerosis obliterans is available.