摘要
目的:研究血脂康对高脂血症患者氧化应激的抑制作用,评估该作用是否独立于降低胆固醇,及氧化应激改变时维生素E的变化。方法:对48例高脂血症患者(高脂血症组)和30名健康受试者作为对照组进行研究,在治疗前对患者的血浆维生素E含量、尿8-异前列腺素F2a、血清总胆固醇进行检验,并对数值进行对比研究。干预治疗时,将48例高脂血症患者随机分为随机饮食组(饮食组)或饮食加服血脂康(治疗组)各24例,分别在第1日、第3日、第60日时测量上述指标并进行比较。结果:与对照组相比,高脂血症组的血清总胆固醇、尿8-异前列腺素F2a含量较高,维生素E含量较低(P<0.05～0.01)。与饮食组比较,治疗组治疗第3日尿8异前列腺素F2a开始减少(P<0.05),第60日时,尿8-异前列腺素F2a明显减少,而维生素E增多,血清总胆固醇降低(均为P<0.05)。结论:应用辛伐他汀进行治疗,可以在疾病早期降低尿8-异前列腺素F2a,减轻患者的氧化应激的表现。
Objective：To study the effect of Xuezhikang on oxidative stress in patients with hyperlipidemia inhibition is independent assessment of the role of cholesterol, and oxidative stress changes, vitamin E, changes. Methods ： 48 patients with hyperlipidemia （ hyperlipidemia group ） and 30 healthy subjects （ control group） were measured before treatment serum total cholesterol,urinary 8 -iso prostaglandin F2a and plasma vitamin E content and compared. Intervention treatment,48 patients with hyperlipidemia were randomly divided into random diet （ diet group） or diet plus service Xuezhikang （ treatment group） of the 24 cases, respectively,in the first 1, No. 3, when the first 60 days measure and compare these indicators. Results：Compared with the control group, hyperlipidemia group, serum total cholesterol,urinary 8 - isoprostaglandin F2, high content of vitamin E content was lower （ P 〈 0. 05 - 0.01 ）. Compared with the diet group, day 3 treatment group differences in urine 8 - prostaglandin F2a started to decrease （P 〈 0. 05 ） , the first 60 days, the urinary 8 - iso prostaglandin F2, decreased, while vitamin E increased serum total cholesterol （both P 〈 0.05 ）. Conclusion ： The application of simvastatin in patients with hyperlipidemia, in the early to reduce urinary 8 - iso prostaglandin F2a, reduce oxidative stress, and this effect is not dependent on lipid lowering, with the application of time, can also lower total cholesterol, increased circulating levels of antioxidant vitamins E.
出处
《医学信息（中旬刊）》
2011年第6期2559-2560,共2页
Medical Information Operations Sciences Fascicule
基金
湖南省教育厅课题(10C0048)
