摘要
microRNAs（miRNAs）是近年来发现的普遍存在于动植物体内的一类非编码RNA,传统观点认为,它们通过其种子序列定位于靶mRNA的3′非编码区,并发挥抑制靶mRNA翻译的作用.最新的研究揭示少数miRNAs也可以活化翻译,且这些现象的发生均与miRNA和翻译调控元件的相互作用有关.这些发现进一步扩展了对微小RNA功能的认识领域.
MicroRNAs （miRNAs） are a recently found class of non-coding RNAs and widely exist in plants and animals. In general, miRNAs play a negative role in regulation of gene translation by binding to the 3 UTR of target mRNA. Recent reports have indicated that some miRNAs can also activate translation. This up-regulation of gene expression by miRNAs has been found to be related to the interaction between miRNA and translational control elements.
出处
《医学分子生物学杂志》
CAS
CSCD
2011年第3期273-277,282,共6页
Journal of Medical Molecular Biology
基金
广东省医学科研基金（No.B2009614）
