双环醇片防治肿瘤化疗药物性肝损害的研究

Study of bicyclol in the prevention and treatment of hepatic damage caused by chemotherapy

目的:评价双环醇片对肿瘤化疗药物所致肝损害的治疗和预防作用。方法:随机选取62例初次肿瘤化疗后出现药物性肝损害的患者,开始口服双环醇片50mg每日3次。待肝功能恢复正常后再次按照原方案化疗时,继续口服双环醇片50mg每日3次,持续14d,前后进行自身对照。观察口服双环醇片对肿瘤患者化疗后肝损害所致谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBiL)等肝功能的影响。同时,观察口服双环醇片治疗肿瘤化疗药物所致肝损害恢复正常后,化疗同时联合双环醇片预防性保肝治疗,比较该次与单纯化疗前后的ALT、AST、TBiL差值。结果:口服双环醇片治疗化疗后肝损害,肝功能ALT、AST等指标明显降低,在中位时间8.5d恢复正常。在预防化疗所致肝损害上,化疗与双环醇片联合治疗前后的ALT、AST差值明显减小,与单纯化疗前后比较,差异有统计学意义(P<0.01)。结论:双环醇片可以有效治疗和预防化疗药物对肝脏的损害。

Objective：To evaluate the efficacy of bicyclol in the prevention and treatment of hepatic damage caused by chemotherapeutic drugs.Methods：Sixty-two patients with hepatic damage caused by chemotherapy were randomly chosen to receive bicyclol 50 mg tid orally after they were found hepatic damage caused by chemotherapeutic drugs.The influence of Bicyclol to ALT,AST,TBiL of cancer patients were observed after liver damage induced by Chemotherapy.After the recovery of the liver damage of these patients,the prophylactically protective effects of bicyclol to liver damage were also studied by combination cure of bicyclol and chemotherapy.Results：Bicyclol could obviously reduce the elevated ALT and AST level caused by chemotherapy.When used as a preventive medicine,combination cure of Bicyclol and Chemotherapy had protective effect to liver damage compared with Chemotherapy without Bicyclol（P0.01）.Conclusion：Bicyclol can effectively treat and protect the liver damage caused by Chemotherapy.