摘要
目的观察和分析利塞膦酸钠对去势骨质疏松白兔的治疗作用。方法观察利塞膦酸钠(2,5mg.kg-1.d-1)对实验性骨质疏松白兔血清碱性磷酸酶活性,血钙,血磷值,股骨骨密度及骨小梁宽度的影响。结果与对照组相比,利塞膦酸钠可明显增加去势所致骨质疏松白兔血清ALP、血钙值(P<0.01),股骨骨密度及骨小梁宽度的测定与对照组相比有显著差异(P<0.01),血磷值无明显差异(P>0.05)。结论利塞膦酸钠对去势所致骨质疏松白兔有明显的治疗作用。
Objective To obeserve and analyze of risedronate for osteoporosis inovariectomized rabbits therapeutic effect.Methods 21 rabbits were divided into 3 groups：contro group,OP and treated with risedronate at a low dose（2 mg·kg-1·d-1）and OP and treated with risedronate at a high dose（5mg·kg-1·d-1）.OP was induced by ovariectomized.The studies were carried out to determine the effect of risedronate on serum ALP,serum calcium,BMD and bone trabeculae.Results Compared with the control group,risedronate significantly increased due to osteoporosis in ovariectomized rabbit serum ALP,serum calcium（P0.01）,femoral bone mineral density and trabecular bone measured the width of the control group there were significant differences（P0.01）,serum phosphorus value was no significant difference（P0.05）.Conclusion The result of risedronate for osteoporosis in overiectomized rabbits have signifcant therapeutic effect.
出处
《颈腰痛杂志》
2011年第3期187-189,共3页
The Journal of Cervicodynia and Lumbodynia
