癌性恶病质与细胞因子相关性的临床研究

Relationship of cytokine level with cancer cachexia and its clinical research

目的探讨细胞因子在癌性恶病质患者中的表达情况及与癌性恶病质发生、发展的相关性。方法对80例癌性恶病质患者、40例门诊体检的健康人和40例非恶病质癌症患者血清中的IL-1、IL-6、TNF-α、IFN-γ水平相互比较。对80例癌性恶病质患者,采用甲羟孕酮片及营养支持治疗4周后检测其血清中的IL-1、IL-6、TNF-α、IFN-γ的水平,并与治疗前的水平进行比较。结果癌性恶病质组与健康组、非恶病质癌症组比较,IL-1、IL-6、TNF-α、IFN-γ水平升高(P<0.05);癌性恶病质组治疗后IL-1、IL-6、TNF-α、IFN-γ水平下降(P<0.05)。结论细胞因子与癌性恶病质的发生、发展相关,并扮演着重要的角色。

Objective To study the expression of cytokine in the cancer cachexia patients and to discuss the relationship with cancer cachexia.Methods To compare the IL-1、IL-6、TNF-α、IFN-γ levels with 80 cases patients of cancer cachexia、40 cases healthy people and 40 cases patients of non-cancer cachexia.To oral medroxyprogesterone with the 80 cases patients of cancer cachexia and give the nutritional support of four weeks.Four weeks later,to detect the levels of IL-1、IL-6、TNF-α、IFN-γand compare with pre-treatment.Results Compared cancer cachexia group with non-cancer cachexia group and healthy group,the levels of IL-1、IL-6、TNF-α、IFN-γ increased.P0.05,there were significances in statistics;The 80 cases patients of cancer cachexia through four weeks treated,the levels of IL-1、IL-6、TNF-α、IFN-γ decreased.P0.05,there were significances in statistics.Conclusion Cytokines are relevant to the cancer cachexia and playing an important role.