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缺血后适应对局灶性脑缺血/再灌注大鼠p38表达的影响 被引量：3

Effect of ischemic postconditioning on the expression of P38 after focal cerebral ischemia reperfusion in rat
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摘要 目的:探讨缺血后适应对大鼠局灶性脑缺血/再灌注损伤后p38表达的影响。方法:将30只雄性SD大鼠随机分为3组(n=10):假手术组(sham组)、缺血/再灌注(I/R)组和缺血后适应(IP)组。利用TUNEL法观察神经细胞凋亡的变化,应用Westernblot检测大鼠局灶性脑I/R损伤后p38蛋白表达水平的变化。结果:大鼠脑缺血/再灌注后凋亡细胞数量和p38蛋白表达水平均显著升高,而IP组凋亡细胞数量和p38蛋白表达水平均显著低于IR组(P<0.01)。结论:缺血后适应可抑制大鼠脑缺血/再灌注后细胞凋亡的发生,此作用可能与下调p38蛋白表达有关。
作者 武慧丽 赵永青 侯亚红 王雪莲
机构地区 武警医学院附属医院神经科 武警海南总队医院
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2011年第2期178-179,191,共3页 Chinese Journal of Applied Physiology
关键词 缺血后适应 缺血/再灌注 细胞凋亡 P38 ischemic postconditioning ischemia/reperfusion apoptosis p38
分类号 R349.54 [医药卫生—基础医学]
  • 相关文献

参考文献5

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二级参考文献12

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共引文献5

同被引文献56

  • 1林海平,王永,沈燕,王舒.大鼠脑缺血再灌注损伤中细胞凋亡相关调控因子的研究进展[J].中国老年学杂志,2014,34(9):2589-2592. 被引量：13
  • 2Chan PH. Role of oxidants in ischemic brain damage. Stroke, 1996, 27: 1124-1129.
  • 3Zhao H. Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J Cereb Blood Flow Metab, 2009, 29: 873-885.
  • 4Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with isehemic preconditioning Am J Physiol Heart Circ Physiol, 2003, 285: H579-H588.
  • 5Zhao H, Sapolsky RM, Steinberg GK. Interrupting reperfusion as astroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab, 2006, 26: 1114- 1121.
  • 6Ran C, Gao X, Niu G, et al. Delayed postconditioning protects against focal ischemic brain injury in rats. PLoS One, 2008, 3: e3851.
  • 7Ren C, Yah Z, Wei D, et al. Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res, 2009, 1288: 88-94.
  • 8Zhao H, Ren C, Chen X, et al. From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia. Curt Drug Targets, 2012, 13: 173-187.
  • 9Gao X, Ren C, Zhao H. Protective effects of ischemic postcondi- tioning comp ed with gadual reperfusion or preconditioning J Neurosci Res, 2008, 86:2505-2511.
  • 10Wang JY, Shen J, Gao Q, et al. Isebemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. Stroke, 2008, 39: 983-990.

引证文献3

二级引证文献13

中国应用生理学杂志
2011年 第2期

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