奥氮平治疗老年期痴呆行为和精神障碍对照研究

Comparative study of olanzapine in the treatment of patients with senile dementia accompanied with behavioral and mental symptoms

目的:探讨奥氮平对老年期痴呆患者的行为和精神症状的疗效及不良反应。方法:80例老年期痴呆患者随机分为奥氮平组38例和奎硫平组42例,疗程8周。采用阿尔茨海默病病理行为评定量表(BEHAV-AD)及治疗中出现的症状量表评定疗效和不良反应。结果:治疗后两组BEHAV-AD评分均显著下降(P<0.05或P<0.01);以奥氮平组BEHAV-AD总分及行为紊乱、抑郁、焦虑评分降低明显(P<0.05)。结论:奥氮平对老年期痴呆的行为和精神障碍患者安全有效,适合临床应用。

Objective： To evaluate the efficacy and adverse effects in patients with senile dementia accompanied with behavioral and mental symptom treated by olanzapine. Method：Eighty patients with senile dementia were randomly divided into olanzapine group （n = 38 ） and quetiapine group （n = 42 ） for 8weeks. Behavioral pathology in Alzheimer disease rating scale （BEHAVE-AD） was used to access the efficacy and treat- ment emergent symptoms scale（TESS） was used to evaluate the adverse effects. Results：The scores of BEHAVE-AD in both group after treatment were all significantly lower than those in baseline （ P 〈 0.05 or P 〈 0.01 ） ; the total scores of BEHAVE-AD, depression and anxiety were significanty lower in olanzapine group （P 〈 0. 05）. Conclusion： Olanzapine was effective and safe in the treatment of patients with senile dementia and was suitable for clinical use.