摘要
目的:比较度洛西汀与西酞普兰治疗不同症状抑郁症的疗效。方法:将122例符合国际疾病分类第10版抑郁症诊断标准的患者,按不同主诉(精神症状或躯体症状)分为精神症状组60例和躯体症状组62例,每组再随机分为度洛西汀组(30例/30例)和西酞普兰组(30例/32例),分别给予度洛西汀和西酞普兰治疗6周。用汉密尔顿抑郁量表17项(HAMD)评定疗效,用治疗中出现的症状量表(TESS)评定不良反应。结果:在以精神症状为主的患者中,度洛西汀组与西酞普兰组疗效比较差异无显著性(P>0.05);在以躯体症状为主的患者中,以度洛西汀组显效率(76.67%)高于西酞普兰组(53.12%),两组比较差异有显著性(P<0.05)。结论:度洛西汀和西酞普兰治疗抑郁症均有效,但度洛西汀起效较快,治疗伴有躯体症状的抑郁症疗效更好。
Objective: To compare efficacy of duloxetine and citalopram in the treatment of depression with different symptoms. Method: 122 patients meeting with ICD-10 for depression were divided into psychotic symptom group ( n = 60) and somatic symptom group ( n = 62), according to their different complaints. Then psychotic symptom group and somatic symptom group were randomly divided into two sub-groups respectively, duloxetine sub-group ( n = 30/30 ) and citalopram sub-group ( rr = 30/32 ) for 6 weeks treatment. The efficacy and the safety were assessed by Hamilton depression scale (HAMD) and the treatment emergent symptom scale (TESS), respectively. Results:There was no significant difference in the efficacy between duloxetine sub-group and citalopram sub-group in the treatment of depressed patients predominant in psychotic symptoms. The response rate was significantly higher in patients of duloxetine sub-group compared with that in eitalopram sub-group 76.67% vs. 53.12% ( P 〈 0.05 ) in the treatment of depressed patients predominant in somatic symptoms. Conclusion: Both duloxetine and citalopram were effective in the treatment of depression, with duloxetine response earlier and more effective in the treatment of depressed with somatic symptoms.
出处
《临床精神医学杂志》
2011年第3期193-194,共2页
Journal of Clinical Psychiatry