度洛西汀与西酞普兰治疗抑郁症的对照研究

A comparation study of duloxetine and citalopram in the treatment of depression

目的:比较度洛西汀与西酞普兰治疗不同症状抑郁症的疗效。方法:将122例符合国际疾病分类第10版抑郁症诊断标准的患者,按不同主诉(精神症状或躯体症状)分为精神症状组60例和躯体症状组62例,每组再随机分为度洛西汀组(30例/30例)和西酞普兰组(30例/32例),分别给予度洛西汀和西酞普兰治疗6周。用汉密尔顿抑郁量表17项(HAMD)评定疗效,用治疗中出现的症状量表(TESS)评定不良反应。结果:在以精神症状为主的患者中,度洛西汀组与西酞普兰组疗效比较差异无显著性(P>0.05);在以躯体症状为主的患者中,以度洛西汀组显效率(76.67%)高于西酞普兰组(53.12%),两组比较差异有显著性(P<0.05)。结论:度洛西汀和西酞普兰治疗抑郁症均有效,但度洛西汀起效较快,治疗伴有躯体症状的抑郁症疗效更好。

Objective： To compare efficacy of duloxetine and citalopram in the treatment of depression with different symptoms. Method： 122 patients meeting with ICD-10 for depression were divided into psychotic symptom group （ n = 60） and somatic symptom group （ n = 62）, according to their different complaints. Then psychotic symptom group and somatic symptom group were randomly divided into two sub-groups respectively, duloxetine sub-group （ n = 30/30 ） and citalopram sub-group （ rr = 30/32 ） for 6 weeks treatment. The efficacy and the safety were assessed by Hamilton depression scale （HAMD） and the treatment emergent symptom scale （TESS）, respectively. Results：There was no significant difference in the efficacy between duloxetine sub-group and citalopram sub-group in the treatment of depressed patients predominant in psychotic symptoms. The response rate was significantly higher in patients of duloxetine sub-group compared with that in eitalopram sub-group 76.67% vs. 53.12% （ P 〈 0.05 ） in the treatment of depressed patients predominant in somatic symptoms. Conclusion： Both duloxetine and citalopram were effective in the treatment of depression, with duloxetine response earlier and more effective in the treatment of depressed with somatic symptoms.