阿立哌唑治疗抗精神病药所致闭经的精神分裂症对照研究

A comparison study of aripiprazole in the treatment of schizophrenic patients with amenorrhea induced by antipsychotics

目的:探讨阿立哌唑对抗精神病药所致闭经的精神分裂症患者的影响。方法:69例抗精神病药引起闭经的女性精神分裂症患者,随机分为A组(单用阿立哌唑治疗)34例和B组(用其他抗精神病药联合中药血府逐瘀汤治疗)35例,观察疗程3个月。于治疗前、治疗后1、2、3个月测定血清催乳素浓度,并评定闭经的疗效。结果:治疗后两组血清催乳素浓度均较治疗前降低;以A组血清催乳素浓度(15.21±6.17)μg/L显著低于B组(85.91±24.86)μg/L(t=-15.870,P=0.000);A组闭经治疗总有效率100%显著高于B组84.85%(χ2=67.00,P=0.000)。结论:阿立哌唑治疗因抗精神病药所致闭经的精神分裂症患者安全、有效。

Objective： To study the clinical effect of aripiprazole in the treatment of schizophrenic patients with amenorrhea induced by antipsychotics. Method：69 female schizophrenic patients with amenorrhea induced by antipsychotics were randomly divided into two groups, group A （n = 34, treated by aripiprazole） and group B （n = 35, treated by other antipsychotics combined with traditional Chinese medicine Xuefuzhuyu soup）, for 3 months treatment. The serum level of prolactin was measured before and after 1,2 and 3 months treatment. The efficacy on amenorrhea was evaluated. Results ：The serum level of prolactin decreased in both group after treatment, with significant decrease in group A compared with that in group B[ （15.21 ± 6.17）μg/L vs. （85.91± 24.86）μg/L（ t = - 15. 870,P = 0. 000）. The total treatment response rate for amenorrhea was 100% in patients of group A, significantly higher than that 84.85% in group B （X2 = 67.00, P = 0. 000 ）. Conclusion：Aripiprazole can treat amenorrhea induced by antipsychotics in patients with schizophrenia efficaciously and safely.