肝动脉栓塞化疗对原发性肝癌患者肝纤维化指标的影响

Influence of Transcatheter Arterial Embolism on the Fibrogenic Indicators in Patients with Primary Hepatocellular Carcinoma

为探讨重复肝动脉化疗（TAE）对原发性肝癌（PHC）患者肝脏损伤的影响，对40例经3次TAE治疗的PHC患者和25例肝血管瘤患者（经1次TAE治疗）测定治疗前后透明质酸（HA），层粘连蛋白（LN），人Ⅲ型前胶原（HpcⅢ）和Ⅳ型胶原（Ⅳ·C）的含量。结果发现第2次TAE治疗后，上述4项指标TAE前后均有显著性差异（P＜0．05），以第3次TAE后升高最为明显（P＜0．01）。提示重复TAE治疗常可加重PHC患者的肝损害，应引起足够的重视。

To investigate the influence of transcatheter arterial embolism (TAE) on the hepatic damage of patients with primary hepatocellular carcinoma (PHC), the contents of serum procollagen type-Ⅲ (hpc- Ⅲ ),collagen type- Ⅳ (Ⅳ·C), hyaluronate acid (HA) and laminin (LN) of 40 patients with PHC receiving curation of TAE for 3 times and 25 patients with liver hemangioma undergoing once curation of TAE were determined. As compared to those before curation of TAE, the above 4 fibrotic indicators showed a significant change (P<0. 05) after the second curation of TAE and more significant change after the third curation of TAE (P<0. 01). However, no significant changes in the 4 indicators were found in the patients with liver hemangioma before and after the curation of TAE (P>0. 05). The results demonstrated that the repeated curation of TAE might intensify the damage to the liver.