库存全血抗凝血酶Ⅲ及蛋白C变化的研究

Changes in Antithrombin-Ⅲ and Protein-C in Stored Blood

对15名健康献血员4℃库存血进行了抗凝血酶Ⅲ活性及蛋白C抗原含量的动态观测。结果发现，抗凝血酶Ⅲ活性在采血后12h内活性即明显下降，在贮存3d时活性下降超过50％，在贮存7d时失去70％左右的抗凝活性，蛋白C抗原含量较稳定，在贮存第4d开始下降，贮存第30d下降才达50％以上。因此认为，在临床补充抗凝成份替代疗法中，输注贮存3d以内血液有可能补充一定量的抗凝血酶Ⅲ，而1月以内的贮存血可补充蛋白C。

Activities of antithrombin- Ⅲ (AT- Ⅲ ) and protein-C in storedblood (4℃ ) were observered in 15 health blood donors. The results showed that AT- Ⅲ activity decreased obviously 12 h after blood drawing.AT- Ⅲ activity was decreased by over 50 % in 3 days and 70 % in 7 days. Protein-C antigen content remained stable, started to decline on the 4th and was decreased by 50 % on the 30 th day. From the results, it was suggested that the stored blood in 3 days could be used as replacement therapy after complement of AT- Ⅲ, while the stored blood in 30 days could be used after complement of protein-C.