正常人中央角膜厚度对不同眼压计测量值的影响

Effect of Central Corneal Thickness on Intraocular Pressure Measured by Three Tonometers in Normal Subjects

目的探讨正常人中央角膜厚度(central corneal thickness,CCT)对Icare回弹式眼压计(Icare rebound to-nometer,Icare)、Goldmann压平眼压计(Goldmann Applanation Tonometer,GAT)和PASCAL动态轮廓眼压计(DynamicContour Tonometry,DCT)眼压测量值的影响。方法采用Icare、GAT和DCT同时测量99例正常人共185眼的眼压,使用NIDEK UP-1000型角膜测厚仪测定CCT。采用重复测量数据的方差分析比较Icare、GAT和DCT眼压测量值之间的差异,眼压测量值的两两比较采用多个样本均数间的多重比较,眼压测量值的两两相关关系采用Pearson线性相关分析,CCT与3种眼压计眼压测量值的相关性采用Pearson线性相关及回归分析。结果 Icare、GAT和DCT测得的眼压平均值分别为(16.89±3.57)mmHg(1mmHg=0.133kPa)、(16.28±3.33)mmHg、(15.57±2.57)mmHg,3种眼压计的测量结果有统计学差异(F=8.042,P<0.001);Icare与GAT,Icare与DCT,GAT与DCT眼压测量值均呈正相关,相关系数(r)分别为0.879(P<0.001),0.583(P<0.001),0.678(P<0.001);Icare和GAT的眼压测量值与CCT均呈正相关,相关系数分别为0.478(P<0.001),0.443(P<0.001),而DCT的眼压测量值则与CCT无显著相关关系(r=0.100,P=0.175),Icare与DCT、GAT与DCT眼压测量值的差值与CCT有显著相关性,r均为0.493(P<0.001),而Icare与GAT眼压测量值差值与CCT无显著相关性,r为0.137(P=0.063)。结论正常人DCT眼压测量值不受CCT影响,Icare、GAT眼压测量值均受CCT影响,两者受CCT影响的差别不显著。

Objective To study the effect of central corneal thickness（CCT） on the intraocular pressure（IOP） measured by Icare rebound tonometer（Icare）,Goldmann Applanation Tonometer（GAT） and Dynamic Contour Tonometry（DCT）.Methods IOP of 99 normal persons（185 eyes） was measured using Icare,GAT and DCT.CCT was measured using NIDEK-UP-1000.ANOVA of repeated measurement data and multiple comparison was applied to compare the IOP values measured by Icare,GAT and DCT.The pair-wise correlation was evaluated by Pearson correlation analysis.The effect of CCT on IOP measured by Icare,GAT and DCT was assessed by Pearson correlation analysis and linear regression analysis.Results The mean IOPs measured by Icare,GAT and DCT were（16.89±3.57）mmHg（1mmHg=0.133kPa）,（16.28±3.33）mmHg and（15.57±2.57）mmHg respectively（significantly different,F=8.042,P0.001）.They had positive pair-wise correlations,the correlation coefficient（r） between Icare and GAT was 0.879（P0.001）,r between Icare and DCT was 0.583（P0.001）,and r between GAT and DCT was 0.678（P0.001）.IOPs measured by Icare and GAT had positive correlation with CCT（r=0.478,P0.001;r=0.443,P0.001） and IOP measured by DCT had no significant correlation with CCT（r=0.100,P=0.175）.The differences of measured IOPs between Icare and DCT,GAT and DCT were significantly correlated with CCT（both r=0.493,P0.001）,and the difference of IOPs between Icare and GAT had no significant correlation with CCT（r=0.137,P=0.063）.Conclusion In healthy eyes,CCT doesn＇t affect the IOP measurement by DCT,but has similar affection the IOP measurement by Icare and GAT.