体检人群中高尿酸血症与脂肪肝的相关性

Association between Hyperuricemia and Fatty Liver

目的描述高尿酸血症和脂肪肝在健康体检人群中的检出率,探索高尿酸血症与脂肪肝的相关性,指导临床对高尿酸血症患者的诊治。方法对2008年2074位来本院健康体检人群进行横断面调查,描述高尿酸血症和脂肪肝在健康体检人群中的检出率,通过双变量分析和Logistic多元回归分析,探索高尿酸血症和脂肪肝的相关性。结果该人群中总高尿酸血症检出率为14.3%,其中男性检出率为21.4%,女性为11.5%;该人群中脂肪肝总检出率为40.28%,其中男性为47.3%,女性为37.4%。脂肪肝组血清尿酸浓度明显升高,高尿酸血症组脂肪肝检出率明显升高;即便在正常范围内脂肪肝检出率随血清尿酸水平升高而升高,调整脂肪肝其他混淆因素后,脂肪肝检出率仍随血清尿酸浓度升高而升高。结论高尿酸与脂肪肝独立相关。

Objective To describe the prevalence of hyperuricemia and fatty liver in the health examination population and explore the association between them.Methods A cross-sectional study was conducted in the population who ran health examination in 2008 in our hospital.The prevalence of hyperuricemia and fatty liver was described,and the association between them was analyzed by bivariate analysis and logistic multiple regression.Results The detection rate of hyperuricemia was 14.3% while that of fatty liver was 40.28%;The fatty liver patients had high concentrate of serum uric acid,while the detection rate of fatty liver was significantly high in the hyperuricemia patients.The detection rate of fatty liver was positively associated with concentrate of serum uric acid even in the normal extent.The association was still present after adjusted all the confounder.Conclusion Hyperuricemia is independently associated with fatty liver.