海南省蜉蝣过敏原临床致敏性

Allergenicity of Ephemeroptera Allergen in Allergic Rhinitis Patients of Hainan Province

目的了解海南省临床蜉蝣过敏情况,为过敏性鼻炎的流行病学研究及临床诊断、治疗和预防提供依据。方法对500例过敏性鼻炎患者用蜉蝣过敏原进行前臂皮肤点刺试验,然后随机选择20例蜉蝣点刺阳性患者进行蜉蝣过敏原鼻黏膜激发试验。结果 500例皮肤点刺试验中,蜉蝣阳性者占58.6%(293/500),20例阴性对照者皮肤点刺均为阴性100%(20/20);20例蜉蝣皮肤点刺阳性患者中过敏原鼻黏膜激发试验阳性者为20例(100%),20例阴性对照未见阳性反应。结论皮肤点刺和过敏原鼻黏膜激发试验结果相符合,蜉蝣为海南省重要过敏原。

Objective To investigate the allergenicity of Ephemeroptera allergen in allergic rhinitis （AR） patients of Hainan province,as a basis for epidemiological survey,clinical diagnosis,treatment and prevention.Methods 500 patients with allergic rhinitis were detected with Ephemeroptera allergen extract by skin prick test （SPT）,and 20 cases of the SPT positive patients were chosen randomly to be prescribed the nasal provocation test.Allergen extract was produced by Beijing MacroUnion Pharmaceutical Co.,Ltd.Results 293 cases in AR group showed positive SPT results;the positive rate was 58.6% （293/500）.All the SPT results were negative in 20 cases in control group;the negative rate was 100% （20/20）.All the nasal provocation test results were positive in 20 cases positive SPT patients,while all negative in 20 cases of control group.Conclusion The SPT results were shown to accord with the results of nasal provocation test.Ephemeropterais one kind of important inhalant allergens in Hainan province,which provide evidence as a basis for clinical diagnosis,treatment,prevention and specific immunotherapy in allergic disease patients in Hainan province.