非诺贝特对乳源县瑶族高脂血症患者的干预作用及血管内皮功能的影响

目的观察乳源县瑶族人群的血脂水平,运用非诺贝特进行早期干预,探讨对血脂水平及血管内皮功能的影响。方法将符合标准的患者随机分为非诺贝特高、低剂量组,并与正常组对照,干预8周,观察各组治疗前后的血压、血清甘油三酯(TG)、总胆固醇(TC)、空腹血糖(GLU)水平,酶比色法检测NO浓度,酶联免疫吸附法检测血浆可溶性VCAM-1浓度(sVCAM-1)浓度。结果非诺贝特可显著改善高脂血症患者血压、血脂及血糖水平,增加血清NO水平,降低sVCAM-1浓度。结论运用非诺贝特对瑶族人群中高脂血症患者进行早期干预,可显著改善血脂水平、降低血糖,其机制可能通过增加NO释放,抑制sVCAM-1生成,从而改善血管内皮功能实现的。

Objective To observe the lipid levels in Ruyuan Yao population and to explore the effect of early intervention with fenofibrate on lipid levels and endothelial function. Methods Patients with hypertriglyceridemia were randomly divided into high dose and low dose group and receive fenofibmte treatment（400 and 200mg/d respectivly）for 8 weeks. 30 healthy controls were chosen as the normal group. Blood pressure,serum tdglyeeride（TG）,total cholesterol（TC）, fasting blood glucose（GLU）levels, NO concentration and plasma soluble VCAM-I（sVCAM-1）were measured before and after treatment. Results 8-week treatment with fenofibrate significantly reduced the elevated levels of blood pressure, TG, TC, GLU and the concentration of VCAM-1 and attenuated the decreased level of NO and improved endothelial function. Conclusion The early intervention with fenofibrate on patients with hyperlipidemia could significantly attenuate lipid and blood sugar levels, which may be by increasing NO release and inhibition of sVCAM-1 generation to improve vascular endothelial function.