摘要
目的:观察放射治疗配合紫杉醇化疗对食管癌的临床疗效。方法:对173例食管癌病人根据不同的治疗方法分为两组:单纯放射治疗组(单放组)和放射治疗同步化疗组(放化疗组)。单放组80例,采用常规设野放疗,DT65-70 Gy;放化疗组93例,放疗方法及剂量同单放组,化疗采用紫杉醇每周同步方案。两组均随访2年。结果:局部近期疗效放化疗组好于单放组,两组有显著性差异(P<0.05)。放化疗组与单放组1、2年生存率单放组为51.3%(41/80)、32.5%(26/80),同步放化疗组为87.19%(81/93)、68.8%(64/93),两组差异有显著性(P<0.05)。结论:同步放化疗优于单纯放射治疗,可明显提高食管癌的疗效。
Objective:To study the effect of radiotherapy combined with paclitaxel chemotherapy on esophageal cancer.Method:173 cases of esophageal cancer were divided into conventional radiotherapy(80 cases) to a total of 65-70 Gy;combined group with received the same radiotherapy as simple irradiation group plus chemotherapy with weekly paclitaxel.Both groups were followed up for 2 years.Result:The short-term results of radiotherapy combined with chemotherapy was better than that of radiotherapy alone.The difference between these two groups was statistically(P〈0.05).The one and two years survival rate were 87%,68.8% in combined.survival rate were 51.3%,32.5% in simple irradiation group.The survival rates in the combined group were thus much better than those in simple irradiation group(P〈0.05).Conclusion:Radiotherapy combined with chemotherapy for advanced esophageal cancer is effective and merits further study in the clinic.
出处
《河北医学》
CAS
2011年第6期714-717,共4页
Hebei Medicine
基金
河北省承德市科研指导计划项目(200621040)