780例心房颤动患者病因及抗凝治疗的临床分析

The Clinical Analysis of Pathogenesis and Anti-coagulation Therapy for 780 Patients with Atrial Fibrillation

目的:探讨心房颤动患者的病因及抗凝治疗特点。方法:对2000年1月至2009年12月在我院住院的780例心房颤动患者的临床资料进行回顾性分析。结果:房颤病因与高血压、冠心病、风心病、肺心病和心肌病显著相关,其中高血压占27.05%、冠心病占26.15%、风心病占25.90%、肺心病占5.13%、心肌病占3.33%。控制心室率主要采用地高辛的患者580例,占74.36%,抗凝治疗使用华法林患者60例,占7.69%,采用阿司匹林抗血小板治疗472例,占60.51%,血栓栓塞事件发生108例,占13.85%。结论:心房颤动患者病因以高血压、冠心病、风心病最多见,控制心室率的治疗以地高辛为主,抗凝治疗中华法林应用不足,血栓栓塞事件发生率高。

Objective：To investigate the situation of pathogenesis and anti-coagulation therapy in patients with atrial fibrillation（AF）.Method：The clinical data of 780 patients with AF who had hospitalized inour hospital from Jun.2000 to Dec.2009,were analyzed retrospectively.Result：Atrial fibrillation and hypertension,coronary heart disease and rheumatic heart disease,lung and cardiomyopathy significant correlation,including hypertension accounted for 27.05%,coronary heart disease accounted for 26.15%,rheumatic accounted for 25.90%,cor pulmonale accounted for 5.13%,cardiomyopathy accounted for 3.33% respectively.Ventricular rate control mainly adopted digoxin patients 580 examples,occupied 74.36%,an-ticoagulation with warfarin 60 cases,accounting for 7.69%,aspirin for antiplatelet therapy 472 cases,accounting for 60.51%.Conclusion：The most important pathogenesis of AF is hypertension,coronary heartdisease and rheumatic valvular heart disease respectively.Digoxin is mainly used in controlling heart rate ofAF.The incidence rate of thromboembolism events is elevated significantly if the application of Warfarin sodium is not enough in patients with AF.