高压氧早期干预缺氧缺血性脑病的评估

Assessment of HBO early intervention in hypoxie ischemic encephalopathy

目的本研究旨在评估高压氧早期干预新生儿缺氧缺血性脑病的作用。方法收集我院新生儿科于2008年1月-2010年10月收治的患儿341例，分为对照组179例和治疗组162例。采用运动发育量表PDMS-2评估治疗前、后治疗的效果，结果治疗后的评分在GMQ[（84．2±19．6）VS（79．7±18．2）]和TMQ【（85．1±21．2）VS（80．6±19．2）]及并发症人数上，治疗组优于对照组，差异均有显著性（P〈0．05）。结论高压氧早期干预能起到明显的治疗效果，但是需要进一步明确高压氧治疗的适应征，以减少可能带来的并发症。

Objective This study aimed to explore the curative effect of hyperbaric oxygen （HBO） for neonatal hypoxic-ischemic encephalopathy （HIE）. Methods New born cases diagnosed with HIE were collected from Jan. 2008 to Oct. 2010. Peabody Developmental Motor Scale -2 was used to evaluate the effect before and after HBO treatment. Among the 341 cases enrolled in the study, all cases were undergone therapy according to the guideline of HIE. Patients were divided into control group （179cases） and treatment group （162cases）. Results GMQ and TMQ scores of treatment group after treatment were （ 84.2 ±19.6 ） and （ 85.1 ± 21.2 ）; while the control group＇ s were （79.7± 18.2）and （ 80.6 ± 19.2 ）. what＇ s more, treatment group had fewer patients got complications than control group. There was significant differences between the two groups（P 〈 0.05）. Conclusion Early HBO treatment of HIE has significant curative effect. It has to fllrther confirm the conditions of patients to reduce the possible complications during HBO treatment.