摘要
目的 观察阿扎司琼联合小剂量地塞米松预防无痛人流术后恶心、呕吐的作用。方法选择ASAⅠ-Ⅱ级择期行无痛人流术患者270例,随机分为A、B、C3组,每组90例;分别静脉注射生理盐水、阿扎司琼及阿扎司琼+地塞米松,3组患者均注射丙泊酚(3mg/kg)及芬太尼(0.6μg/kg),手术24h后电话询问恶心、呕吐发生情况。结果B组(36%)和C组(30%)恶心及恶心伴呕吐发生率均显著低于对照组(87%),差异有极显著性(P〈0.01)组恶心及恶心伴呕吐发生率小于B组,但差异无显著性(P〉0.05)。结论阿扎司琼预防无痛人流术后恶心、呕吐有较好效果,复合小剂量地塞米松并无必要。
Objective To observe the antiemetic effect of azasetron plus low-dose dexamethasone in patients undergoing painless abortion surgery. Methods 270 ASA physical status Ⅰ-Ⅱ patients scheduled for elective painless abortion surgery were randomly divided into 3 equal groups. Patients intravenously received saline (group A), azasetron (group B), azasetron plus low-dose dexamethasone (group C) respectively. Anesthesia was induced with propofol (3 mg/kg) in combination with fentanyl (0.6μg/kg). Patients were interviewed after 24 hours of the surgery by telephone. The incidence of postoperative nausea and vomiting was recorded. Reaults The overall incidence of POVA in group B and C were significantly lower than group A. There was no significant difference between group B and C. Conclusion Azasetron in combination with low-dose dexamethasone produced same antiemetic effect as azasetron alone in patients underwent painless abortion surgery.
出处
《国际医药卫生导报》
2011年第12期1503-1505,共3页
International Medicine and Health Guidance News