血清和支气管肺泡灌洗液多种肿瘤标志物联合检测对肺癌诊断价值的探讨

The Value of Gombined Examinstion of Tumor Markers in BALF and Serum for Diagnosing Lung Cancer

探讨血清和支气管肺泡灌洗液（ＢＡＬＦ）中肿瘤标志物联合检测对肺癌诊断的价值。方法：采用放射免疫分析方法对癌胚抗原（ＣＥＡ）、铁蛋白（ＦＴ）和β_２－微球蛋白（β_２－ＭＧ）进行分析。结果：肺癌患者血清及ＢＡＬＦ中ＣＥＡ、ＦＴ浓度均明显高于肺良性病变组，两组比较有显著性差异（Ｐ＜０．０１或Ｐ＜０．０５）。ＢＡＬＦ中ＣＥＡ、ＦＴ的浓度高于血清浓度，且腺癌ＣＥＡ和ＦＴ浓度高于鳞癌和小细胞未分化癌。β_２－ＭＧ的血清和ＢＡＬＦ浓度两组比较无显著性差异（Ｐ＞０．０５）。结论：肿瘤标志物联合测定可提高肺癌诊断的敏感性、特异性和准确性，对肺癌的早期诊断有辅助价值。

Objective:To study the value of combined examination of tumor markers in bronchoalveolar lavage fluid (BALF) and serum for diagnosing lung cancer. Methods: Carcinoembryonic antigen (CEA), ferritin (FT) and β2-microglobulin (β2-MG) were detected by using radioimmunoassay. Results:The levels of CEA and FT in BALF were higher than those in serum, and the level of CEA of adenocarcinoma was higher than that in squamous cell carcinoma and small cell cancer. There was no significant difference of β2-MG in BALF and serum between lung cancer and non-malignant pulmonary disease.Conclusion: The combined examination of tumor markers in BALF and serum could increase the sensitivity,specificity and crude agree - ment rate for diagnosing lung cancer,and may have the auxiliary clinical value for early diagnosis of lung cancer.