前胡丙素对肾血管性高血压大鼠主动脉平滑肌中AT1受体反应性的影响

Effects of praeupotorin C on blood pressure and responsiveness of angiotensin Ⅱ-1 receptor of aortic artery in renal hypertensive rats

目的 观察前胡丙素（ｐｒａｅｒｕｐｔｏｒｉｎ Ｃ，Ｐｒａ－ Ｃ）对肾血管性高血压（ｒｅｎａｌｈｙｐｅｒｔｅｎｓｉｏｎ．ＲＨ） 模型大鼠主动脉平滑肌中ＡＴ１受体变化的影响。方法 两肾一夹Ｗｉｓｔａｒ 大鼠，术后５ 周给予Ｐｒａ － Ｃ〔２０ ｍｇ／（ｋｇ·ｄ） ，ｉｇ〕，观察大鼠主动脉的血管紧张素（ＡｎｇⅡ）受体第一亚型（ＡＴ１） 的反应性。结果 Ｐｒａ－ Ｃ明显降低ＲＨ 大鼠血压和主动脉对Ａｎｇ Ⅱ的反应性，用药２ 周、４ 周后血压明显下级，分别由治疗前的（２３－６ ±２－１） 降到（１８－６ ±１－８）和（１５－８±１－９） ｋＰａ（Ｐ＜ ０－０１） ；主动脉对Ａｎｇ Ⅱ的最大收缩反应（Ｅｍａｘ） 较对照组（８６３－１６ ±４１－０７）ｍｇ 明显为低，分别为（５４７－２７±３４－５０）ｍｇ，（４８３－１６ ±３１－２６）ｍｇ（Ｐ＜ ０－０１） ，量效曲线向右下移位。结论 Ｐｒａ－ Ｃ 降低血压作用与主动脉ＡＴ１ 受体反应性下降有关。

Objective To observe the effects of praeruptorin C on blood pressure and responsiveness of angiotensin Ⅱ-1 receptor of aortic artery in renal hypertension rats. Method Two-kidney one-clip Wistar hypertensive rats were treated with praeruptorin C 〔Pra-C,20 mg/(kg·d),ig〕for 2 and 4 weeks and the response of aortic artery to angiotensin were studied. Results Pra-C significantly decreased the blood pressure and the response of aortic artery to angiotensin Ⅱ. The blood pressure at 2 and 4 weeks after administration decreased from the control of (23.6±2.1)kPa to (18.6±1.8) kPa and (15.8±1,9)kPa ( P<0 01 );the Emax of vasoconstriction to angiotensin Ⅱ decreased from (863.16±41.07) mg to (547.27±34.50)mg and (483.16±31.26) mg ( P <0 01),with doseresponse curves shifting rightward. Conclusion The effects of Pra-C on blood pressure are related to its effects on the responsiveness of aortic artey AT 1 receptors in renal hypertensive rats.