蜘蛛香的化学成分研究

Study on the Chemical Compositions of Valeriana Jatamansi

目的:对蜘蛛香根中的化学成分进行研究。方法:采用硅胶柱色谱,羟丙基葡萄糖凝胶柱层析Sephadex LH-20及HPLC(高效液相色谱)等分离纯化手段,从蜘蛛香(Valerianajatamansi)根中分离出了17个化合物,通过理化性质和光谱数据分析。结果:分别被鉴定为(3S,4R,5S,7S,8S,9S)-3,8-epoxy-7-hydroxy-4,8-di methylper-hydrocyclopenta[c]pyran(1),(3S,4S,5S,7S,8S,9S)-3,8-ethoxy-7-hydroxy-4,8-di methylperhydrocyclopenta[c] pyran(2),4-β-hydroxy-8-β-methoxy-10-methylene-2,9-dioxatricyclo[4.3.1.03.7]decan(3),6-hydroxy-7-(hydroxymethyl)-4-methyl-enehexahydrocyclopenta[c]pyran-1-(3 H)-one(4),jatamansi A(5),jatamansi G(6),8-hydroxypinoresinol(7),2,5-di(4-hydroxy-3-methoxyphenyl)-1,4-dioxan(8),pinoresinol(9),(+)-2-(3,4-di methoxyphenyl)-6-(3,4-dihydroxyphenyl)-2,7-dioxabi-cyclo[3,3,0]octane(10),pinoresinol monomethyl ether(11),prinsepoil(12),(-)-massoniresinol(13),cinnamolide(14),valeriananoid A(15),valeriananoid C(16)和volvatrate A(17)。结论:化合物3、4和17与化合物7～14为首次在该植物中发现。

Objective:To study the chemical compositions in valeriana jatamansi root.Methods and Results:Silica gel column chromatography,glucose gel hydroxypropyl Sephadex LH-20 column chromatography and HPLC were used to separate 17 compounds from valeriana jatamansi root.Through the analysis of their physical and chemical properties and spectral data,the chemical compositions were identified as(3S,4R,5S,7S,8S,9S)-3,8-epoxy-7-hydroxy-4,8-dimethylper-hydrocycl openta[c]pyran(1),(3S,4S,5S,7S,8S,9S)-3,8-ethoxy-7-hydroxy-4,8-dimethylper-hydrocyclopenta[c]pyran(2),4-β-hydroxy-8-β-methoxy-10-methylene-2,9-dioxatricyclo [4.3.1.03.7]decan(3),6-hydroxy-7-(hydroxymethyl)-4-methyl-enehexahydrocyclopenta[c]pyran-1-(3H)-one(4),jatamansi A(5),jatamansi G(6),8-hydroxypinoresinol(7),2,5-di(4-hydroxy-3-methoxyphenyl)-1,4-dioxan(8),pinoresinol(9),(+)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-2,7-dioxabi-cyclo octane(10),pinoresinol monomethyl ether(11),prinsepoil(12),(-)-massoniresinol(13),cinnamolide(14),valeriananoid A(15),valeriananoid C(16) and volvatrate A(17).Conclusion:Compounds 3,4 and 17 was the first time to find in the plant in the compound 7 to 14.