血清嗜酸性粒细胞阳离子蛋白在冠心病患者中的意义

A Study on the Significance of the Serum Level of Eosinophilic Cation Protein in Coronary Heart Disease Patients

目的通过检测血清嗜酸性粒细胞阳离子蛋白在冠心病患者中的水平,探讨血清嗜酸性粒细胞阳离子蛋白水平与冠心病及其冠状动脉病变严重程度的关系。方法选择冠心病患者70例,非冠心病患者(对照组)30例,进行选择性冠状动脉造影,并根据其冠状动脉病变血管支数将冠心病患者分为单支病变组、双支病变组和三支病变组,分别比较3组之间血清嗜酸性粒细胞阳离子蛋白的水平。结果冠心病组患者血清嗜酸性粒细胞阳离子蛋白水平明显高于对照组(P<0.01);冠心病中冠状动脉单支病变组、双支病变组、三支病变组血清中嗜酸性粒细胞阳离子蛋白水平比较具有统计学意义(P<0.01)。多元线性回归分析显示血清中嗜酸性粒细胞阳离子蛋白与冠状动脉严重程度有密切关系。多元逐步Logistic回归分析显示,血清嗜酸性粒细胞阳离子蛋白水平是冠心病发病的危险因素。结论血清中嗜酸性粒细胞阳离子蛋白水平与冠状动脉病变的进展可能有直接关系。嗜酸性粒细胞阳离子蛋白水平越高,提示冠状动脉病变越严重。

Aim To explore the relationship of serum level of eosinophilic cation protein （ECP） and classifica- tion of coronary artery lesions through measuring their levels. Methods The study enrolls 70 patients with coronary heart disease （ CHD）, and 30 patients without CHD as controls. All patients were confirmed by angiography. According to the number of diseased vessels, we divided the patients into three groups ： 1-vessel disease group, 2-vessel disease group and 3-vessel disease group ; and then analyzed the relationship between the level of ECP and the number of diseased vessels respectively. Results The serum levels of ECP in CHD group were higher than those in control group （ P 〈 0. 01 ）. The relationship between the serum levels of ECP and the number of diseased vessels were statistically related among three groups （P 〈 0. 01 ）. Multiple linear regression analysis showed that levels of ECP were closely associated with the severity of coronary artery lesions. In multivariate analysis, ECP levels were significantly associated with CHD independent of tradi- tional risk factors. Conclusions The study indicates that the higher serum levels of ECP may be related to the initia- tion and development of coronary artery lesions. So the higher serum levels of ECP is likely one of the indexes to predict the severity of the coronary artery lesions.