摘要
动脉桥管在冠状动脉旁路移植术中广泛使用且明显提高了远期效果,但静脉移植物仍然是使用最多的桥管。研究表明静脉移植物10年通畅率约为60%。静脉移植物再狭窄发病机制包括血流动力学变化导致血管壁受损,血栓形成和血管平滑肌迁移、增生,以及随后发生动脉粥样改变等。本文就静脉移植物再狭窄的发生机制作一综述。
Although arterial conduits are widely used and have improved the long-term results of coronary artery bypass grafting, vein grafts remain important additional conduits in coronary surgery. Newer studies show a saphenous vein graft patency of 60% or more at 10 years postoperatively. Vein graft occlusion occurs as a result of neointimal hyperplasia, which takes place in response to hemodynamic changes, vessel wall injury and thrombosis, and is characterized by the migration and proliferation of vascular smooth muscle cells. Intimal hyperplasia is further complicated by the concomitant development of atherosclerosis. In this review we will summarize the pathogenesis of coronary vein graft disease.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第5期451-454,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(NO30571839)
湖北省卫生厅科研基金(JX2B16)资助
关键词
静脉移植物
内膜增生
冠状动脉旁路移植术
Vein Graft
Neointimal Hyperplasia
Coronary Artery Bypass Grafting