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微小RNAs在骨与软骨组织中的调节作用

ROLE OF microRNAs ON REGULATION OF BONE AND CARTILAGE TISSUE
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摘要 目的对微小RNAs(microRNAs,miRNAs)在骨与软骨组织中的调控作用和作用机制作一综述。方法广泛查阅近年来有关miRNAs在骨与软骨组织的调控作用及作用机制的文献,进行总结与分析。结果 miRNAs是近年来骨关节疾病研究的热点,越来越多研究显示其在骨与软骨组织形成和代谢过程中,对于细胞分化、细胞基质分泌等方面发挥重要的调控作用,但确切机制尚不清楚。结论 通过对miRNAs在骨与软骨组织中的调控作用及作用机制的研究,可能为了解退行性骨关节疾病开辟新的领域。 Objective To review the regulation and mechanism of the microRNAs（miRNAs） in the bone and cartilage tissue.Methods Recent literature concerning the regulation and mechanism of the miRNAs in the bone and cartilage tissue was extensively reviewed,summarized,and analyzed.Results Recently miRNAs is a hot topic in the bone and cartilage tissue.More and more materials show its important regulatory role in osteogenesis and cartilage growth and regeneration,but the definite mechanisms have not been clear yet.Conclusion The study on miRNAs of bone and cartilage tissue can provide a new access to understanding the degenerative osteoarthritic diseases.
作者 曾德昕 何成奇
机构地区 长沙民政职业技术学院康复医学系 四川大学华西医院康复科
出处 《中国修复重建外科杂志》 CAS CSCD 北大核心 2011年第6期677-680,共4页 Chinese Journal of Reparative and Reconstructive Surgery
关键词 微小RNAS 成骨细胞 破骨细胞 软骨 软骨细胞 microRNAs Osteoblast Osteoclast Cartilage Chondrocyte
分类号 R684 [医药卫生—骨科学]
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参考文献54

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二级参考文献30

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中国修复重建外科杂志
2011年 第6期

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