脐带Wharton胶来源MSCs生物学特性及其优越性的研究进展

RESEARCH PROGRESS OF BIOLOGICAL CHARACTERISTICS AND ADVANTAGES OF WHARTON'S JELLY-MESENCHYMAL STEM CELLS

目的总结脐带Wharton胶来源MSCs(Wharton’s jelly-MSCs,WJ-MSCs)生物学特性及其优越性的研究进展。方法查阅近年来关于WJ-MSCs的生物学特性及其与脐带血MSCs(umbilical cord blood MSCs,UBMSCs)和BMSCs相比较的文献,进行综述分析。结果从脐带Wharton胶中可分离获得大量具有自我复制、自我更新、高度增殖和多向分化潜能的MSCs。与UBMSCs和BMSCs相比较,WJ-MSCs在分离时间、分离成功率、倍增时间、传代数量和扩增潜能等方面均具有优越性。结论 WJ-MSCs具有取材简便、来源丰富、相对纯净、无伦理问题等优点,是细胞移植治疗、基因治疗和组织工程器官构建的理想种子细胞,为组织再生修复与原位重建提供了新思路。

Objective To summarize the research progress of biological characteristics and advantages of Wharton’sjelly-mesenchymal stem cells（WJ-MSCs）.Methods The related literature on the biological characteristics of WJ-MSCs,umbilical cord blood MSCs（UBMSCs） and bone marrow MSCs（BMSCs） was extensively reviewed and analyzed.Results A large number of MSCs which are able to self-replicate,self-renew and have high proliferation and multipotent differentiation can be isolated from the Wharton’s jelly of umbilical cord.WJ-MSCs have many advantages in isolation time,isolation efficience,expansion time,passage capacity,expansion capacity when compared with UBMSCs and BMSCs.Conclusion WJ-MSCs have numerous advantages of convenient and abundant sources,relatively pure,non-ethical issues,and so on,which can be used for cell transplant therapy,gene therapy,and the ideal seed cells of building tissue engineered organ,so they provide new ideas for tissue regeneration repair and reconstruction.