乙型肝炎病毒表面抗原定量检测的临床应用

Clinical application of quantitative assay of serum hepatitis B surface antigen level

血清或其他体液中检测到乙型肝炎病毒表面抗原(HBsAg)是人体感染乙型肝炎病毒(HBV)最可靠的标志。血清HBsAg水平可随着慢性乙型肝炎的自然病程而变化,并与肝组织中HBV共价闭合环状DNA(HBV cccDNA)水平相关,HBsAg水平还可作为评估干扰素和核苷(酸)类似物抗病毒疗效的一项指标。本文综述HBsAg定量检测在临床中的应用。

The detectable hepatitis B surface antigen （HBsAg） in the blood or other body fluids is the most direct indiction of hepatitis B virus （HBV） infection. The serum HBsAg titer is varied during the natural process of infection correlated with the HBV covalently closed circular DNA （ HBV cccDNA） level in liver. Also, it can be used to evaluate the efficacy of antiviral drugs, including interferon and the nucleoside/nucleotide analogues. This review summarizes the clinical application of HBsAg quantitative assay.