5-氟脲嘧啶选择性碳糊电极的研制与应用

Preparation and Application of Carbon Paste Electrode for 5 _ Fluorouracil

研制了以５ － 氟脲嘧啶离子与汞离子的摩尔比为１ ∶１ 的配位化合物作为电活性物质的５ － 氟脲嘧啶碳糊电极， 得到了良好的电极响应曲线， 线性范围为３ 个数量级， 检出限为１０ － ３ ｍ ｍｏｌ·Ｌ－ １ 。电极稳定性较好， 具有较好的抗干扰能力。采用直接电位法测定商业药品， 结果令人满意。

A carbon paste electrode for the determination of 5 _ fluorouracil(5 _ Fu) was prepared by using complex composed of Hg(Ⅱ) and 5 _ Fu with molar ratio 1∶1 as electrochemically active material. The electrode has a good anti _ interference performance, longer lifetime, wide linear concentration range of three orders of magnitude and the detection limit of 10-3 mmol·L-1. It was used to determine the concentration of 5 _ Fu in injection by direct potentiometry, and satisfactory results with RSD of 3.9%～4.9% and recovery of 94.0%～106.7% were obtained.