重组人脑钠肽治疗肺动脉高压30例临床疗效观察

Clinical observation on rhBNP in treating patients with pulmonary artery hypertension

目的观察肺动脉高压患者静脉应用重组人脑钠肽(rhBNP)的临床疗效。方法肺动脉高压患者60例随机分为2组,治疗组30例,常规治疗基础上静脉应用rhBNP,对照组30例;观察并比较两组治疗前后肺动脉收缩压、肺动脉舒张压、平均肺动脉压、中心静脉压的变化。结果治疗48 h后,两组在降低肺动脉收缩压、肺动脉舒张压、平均肺动脉压方面差异有统计学意义(P<0.05)。结论 rhBNP可用于肺动脉高压的治疗,快速有效,且不良反应少。

Objective To observe effect of intravenous rhBNP on pulmonary artery-hypertension（PAH）.Methods Sixty patients with PAH were enrolled in this study.The patients were randomly allocated to treatment group and control group.Thirty cases received routine treatment,while the other 30 cases received rhBNP besides routine treatment.Patients were evaluated and compared for pulmonary artery systolic pressure,pulmonary artery diastolic pressure,mean pulmonary arterial pressure and central venous pressure.Results Forty-eight hours later,there were significant decrease of PASP,PADP and MPAP in treatment group compared to control group（P0.05）.Conclusion Combined with the standard treatment,rhBNP can be used in pulmonary artery hypertension treatment efficiently,and adverse reactions were less.