雌二醇可降解涂层支架置入后对犬冠状动脉内膜增生的影响

Study on the effect of the neointimal proliferation of canines coronary artery of the stent coated with estradiol

目的探讨雌二醇可降解涂层冠状动脉支架置入后对犬冠状动脉内膜增生的影响。方法以生物可降解高分子聚乳酸为载体,采用共混方法制成雌二醇洗脱冠脉支架。实验分为聚乳酸涂层支架组、雌二醇洗脱支架组、裸支架组,每组犬5只,将相应支架分别置入到每组犬的冠状动脉损伤段,4周后处死,取出支架段血管行病理学观察,计算机图像分析血管总面积(TA)、内膜增生面积(IA)以及面积狭窄百分比。结果雌二醇支架组内膜增生面积较裸支架组及聚乳酸支架组明显减低(P<0.05),聚乳酸支架组内膜增生面积与裸支架组无明显差别(P>0.05)。结论雌二醇洗脱支架较裸支架,可明显加速内皮修复,明显降低再狭窄的发生,是一极具前景研究方向。

Objective To evaluate the effects of the neointimal proliferation of the stent coated with estradiol after percutaneous stent implantation.Methods PLA was used as the carrier,The estradiol was blended with polymer so as to establish estradiol eluting stent.The canines were randomly assigned to three groups（5 canines per group）.PLA eluting stents,estradiol eluting stents,and bare metal stents were deployed into the coronary artery lesion.All canines were euthanized 4 weeks after stenting for histopathological assessment and analyzing lumen area,intimal area and percent area intima by computer graphic technology.Results The intimal area（IA） and percent area intima of estradiol eluting stent group appear smaller than those of bare metal stents group and PLA eluting stent gruoup（P0.05）.there is no statistical difference between the PLA eluting stents group and the bare metal stents group（P0.05）.Conclusion The stent coated with estradiol carried by the degradable polymer maybe useful for reducing in-stent restenosis by accelerating endothelialization compared with the bare metal stent.The research in this field has a splendid future.