摘要
目的探讨内皮抑素(ES)在人脑胶质瘤患者术前及术后血清中的表达水平和意义。方法采用ELISA方法检测46例脑胶质瘤患者术前及术后血清中内皮抑素表达水平,同时选取10例健康人群血清标本作为正常对照。结果健康人群血清中ES平均含量为20.74±1.48 ng/ml,胶质瘤患者术前血清中ES平均含量为26.63±5.63 ng/ml,且随着胶质瘤恶性程度的增加呈升高趋势。结论胶质瘤患者术后5-6天血清中ES平均含量为20.77±3.39 ng/ml,明显低于术前水平。结论血清中内皮抑素的含量水平反映了肿瘤的生长状况,与胶质瘤的恶性程度及预后有关。
Objective To assess the expression and significance of serum endostatin preoperative and postoperative in human glioma.Methods ELISA method was used to detect the expressions of serum endostatin in 46 glioma patients preoperative and postoperative respectively.10 healthy individuals were selected as normal controls.Results The average level of endostatin in healthy individuals was 20.74±1.48 ng/ml,while in glioma patients preoperative was 26.63±5.63 ng/ml,which tended to increase with the increase of glioma pathological grade.On the other side,the average endostatin level in glioma patients postoperative was 20.77±3.39 ng/ml,which was significantly lower than preoperative level.Conclusion The levels of serum endostatin in glioma patients reflected the status of tumor growth and correlated with glioma pathogenic grade and prognosis closely.
出处
《中国实验诊断学》
北大核心
2011年第5期826-828,共3页
Chinese Journal of Laboratory Diagnosis
基金
吉林省科技发展计划项目(20070729-12)
