女性盆腔炎性疾病患者T淋巴细胞亚群变化分析

Female pelvic inflammatory disease of T lymphocyte subsets

目的探讨女性盆腔炎性疾病患者T淋巴细胞亚群的变化。方法选取2008年12月至2010年12月来我院门诊及住院的盆腔炎性相关疾病患者84例,对盆腔炎性疾病患者T淋巴细胞亚群失衡发生率、治疗效果和孕产次与T淋巴细胞失衡的关系进行探讨,同时对两组T淋巴细胞亚群变化进行分析。结果在所研究的84例盆腔炎性疾病患者中,T淋巴细胞亚群失衡率为73.81%;异常组患者孕产≤1次患者所占百分比明显低于正常组患者,异常组患者孕产=2次及孕产≥3次所占百分比明显高于正常组,两组比较差异有统计学意义(P<0.05);与正常组比较,异常组患者CD3+、CD4+及CD4+/CD8+比值显著下降(P<0.05);异常组患者经7d治疗后,患者CD3+、CD4+及CD4+/CD8+比值显著升高,其总有效率为93.55%,与治疗前比较差异有统计学意义(P<0.05)。结论 T淋巴细胞亚群的变化与女性盆腔炎性疾病密切相关,临床治疗该病时应调节机体免疫功能。

Objective To study the female pelvic inflammatory disease T lymphocyte subsets.Methods From December 2008 to December 2010 to our hospital and hospital-related pelvic inflammatory disease,84 cases of pelvic inflammatory disease,T lymphocyte subset imbalance in patients with the incidence,treatment and maternity times and T explore the relationship between lymphocyte imbalance,while two T lymphocyte subsets were analyzed.Results The results of the 84 patients in the studied patients with pelvic inflammatory disease,T lymphocyte subsets imbalance was 73.81%;abnormal pregnancy in patients with ≤ 1 times the percentage of patients was significantly lower than normal patients,patients with abnormal maternal = 2 and ≥ 3 times the percentage of pregnancy was significantly higher than the normal group,the difference was statistically significant（P0.05）;with the normal group,the abnormal group were CD3＋,CD4＋ and CD4＋/CD8＋ ratio decreased significantly（P0.05）;abnormal patients after 7 d after treatment,the patient CD3＋,CD4＋ and CD4＋/CD8＋ ratio increased significantly,the total effective rate was 93.55%,compared with before treatment difference was statistically significant（P0.05）.Conclusion The change in T lymphocyte subsets in female pelvic inflammatory disease and is closely related to the clinical treatment of the disease should regulate immune function.