1Stratton IM,Adler AI,Neil HA,et al.Assceiation of glycaemia with macrovascular and microvascular complications of type 2 diabetes(UKPDS35):prospective observational study.BMJ,2000,321:405-412.
2UK Prospective Diabetes Study Group.UK Prospective Diabetes Study16:overview of 6 years rhe rapy in patients with type 2 diabetes mellitus:a randomized controlled tried.JAMA,2000,283:16957.
3Lebovitz HE.Insulin sectetagogues:old and new.Diabetes,1999,12:139-153.
4Atiderson JH,Brunelle RL,Keohane P,et al.Mealtome treatment with insulin analog improves postprandial hyperglycemia and hypoglyccmia in patients with non-insrlin-dependent diabetesmellituss,Arch Int Med 1997,157:1249-1255.
5Janssen MM,Casteleijin S,Deville J,et al.Nighttime insulin Kinetics and glycemic control in type 1 dibetes patients following admin-istration of an intermediate-acting lispro preparation.Diabetes Care,1997,20:1870-1873.
6De Flippis MR,Bakaysa DL,Bell MA,et al.Preparation and sharacterizeation of a cocrystslline suspendsion of[LysB28PreB29]-human insulin analogue.J Pharm Sci,1998,87:170-176.
7Herz M,Sun B,Milicevic Z,et al.comparative efficacy of preprangial or posprandial Humalog Mix 75/25 versus glyburide in patients 60 to 80 years of age with type 2 dibetes mellitusss.Clin Ther,2002,24:73-76.
8Koivsto VA,Tuominen JA,Ebeling P.Lispro Mix 25 insulin as premeal therapy in type 2 dibetes patients.Dibetes Care,1999,22:459-462.
9Chase HP,Lockspeiser T,Peery B,et al.The impout of the diabetes control and complications trial and human log insulin on glycohemoglobin levels and severe hypoglycemia in type 1 diabetes.Diabetes Care,2001,24:430-434.
3Valensi P, Benroubi M, Borzi V ,et al. Initiating insulin therapy with, or switching existing insulin therapy to, biphasic insulin aspart 30/70 (NovoMixl 30)in routine care: safety and effectiveness in patients with type 2 diabetes in the IMPROVE observational study [J]. Int J Clin Pract,2009,63(2) :522-531.
4Garber A.J,Wahlen J,Wahl T,et al. Attainment of glycaemic goals in type 2diabetes with once- ,twice-, or thrice-daily dosing withbiphasic insulin aspart 70/30(The 1-2-3 study)[J]. Diabetes Obes Metab,2006,8 ( 1 ) :58-66.
5Yoshioka N,Kurihara Y, Manda N,et al. Step-up therapy with biphasic insulin aspart-70/30-Sapporo 1-2-3 study [J]. Diabetes Res ClinPract, 2009,85 ( 1 ) : 47-52.
6Reviriego J, Herzmroach P. Improved glycamic control without increased risk of hypoglyeaemia with a 25% insulin/lispro 75% NPL mixture twicedaily compared with NPL twice daily in patients with Type2 diabetes [J]. J ApplTher Res ,2004,4(5) : 19-25.
7廖二元;超楚生.内分泌学[M]北京:人民卫生出版社,2003.
8Holman RR,Paul SK,Bethel MA. 10-year follow-up of intensive glucose control in type 2 diabetes[J].New England Journal of Medicine,2008,(15):1577-1589.