内质网应激与常见危重症

Endoplasmic reticulum stress in sepsis and ischemia/reperfusion injuries

内质网应激反应是内质网对环境刺激的基本反应，影响细胞生存和死亡。近年研究发现，内质网应激是脓毒症、缺血再灌注损伤等危重症的重要病理生理机制，有望成为这些疾病监测、治疗的合适靶点。本文就内质网应激与上述危重症关系的研究近况做一综述。

Various stresses that interfere with the endoplasmic reticulum function trigger the endoplasmic reticulum stress （ERS） response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or prolonged. Recently, important roles for ERS have been recognized for several severe diseases such as sepsis and isehemia/reperfusion injuries. Improved understanding of ERS in critical care medicine will provide us with new targets for disease surveillance and therapeutic intervention. The present review will focus on this aspect.