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血清CEA水平在大肠癌术后复发早期诊断中的意义探讨 被引量:5

The Value of Serum CEA Level in Prediction of Recurrence in Patients with Colorectal Carcinoma after Surgery
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摘要 目的:探讨血清癌胚抗原(CEA)对大肠癌术后复发的早期诊断价值。方法:检测134例大肠癌患者术前及术后血清CEA值,并随访观察6个月-3年。结果:复发组CEA水平显著高于未复发组CEA水平(P〈0.05),Duke分级越高的术后1个月的CEA的阳性率越高,并且各组之间有统计学差异(P〈0.05)。结论:大肠癌术后定期检测血清CEA的水平能够早期发现其术后的复发和转移。 Objective:To investigate the levels of serum carcino embryonic antigen(CEA)following the operation of colorectal carcinoma.Methods:Serum levels of CEA in 134 patients with colorectal carcinoma before and after operation were detected,who were followed up from six months to three years.Results:The levels of serum CEA in the recurrence group were higher than unrecurrence group(P0.05),and also that the levels of serum CEA were correlated to the pathological stages(Duke staging).It had a significant difference between two groups(P0.05).Conclusion:The results suggests that serum CEA is an valuable marker for the early dignosis of colorectal carcinoma recurrence and metastases after operation.
出处 《医学理论与实践》 2011年第11期1251-1252,共2页 The Journal of Medical Theory and Practice
关键词 癌胚抗原 结肠直肠肿瘤 肿瘤分期 Carcino embryonic antigen Colorectal carcinoma Neoplasm staging
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  • 1[2]尹伯元.放射免疫分析在医学中的应用[M].北京:原子能出版社,2001.316-318.
  • 2Kishimoto Y,Yashima K,Morisawa T,et al.Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane[J].J Gastroenterol,2002,37(3):186-193
  • 3Morin PJ,Vogelstein B,Kinzler KW,et al.Apoptosis and APC in colorectal tumor igenesis[J].Proc Natl Acad Sci USA,1996,93:7950-7954
  • 4Miettinen M,Monihan JM,Sarloml-Rikala M et al.Gastrointestimal stromal tumors/smooth muscle tumors(GISTs) primary in the omentum and mesentery[J].Am J Surg Pathol,1999,223:1109-1118
  • 5Arap W,Nishikawa R,Furnari FB,et al.Rep lacement of the p16/CD2KN2 gene supp resses human glioma cell growth[J].Cancer Res,1995,55(6):135-141
  • 6Morgan RJ,Newcomb PV,Bailey M,et al.Loss of heterozygosity at microsatellite marker sites for tumor supp ressor genes in esophageal adenocarcinoma[J].Int J Surg Oncol,1998,24(1):34-37
  • 7Tada T,Watanabe T,Kazama ZS,et al.Reduced P16 expression correlates with lymphatic invasion in colorectal cancer[J].Hepatogastroenterology,2003,50 (54):1756-1760
  • 8Spillare EA,Odamoto A,Hagiwra K,et al.Suppression of growth in vitro and tumorigencity in vivo of human carcinoma cell lines by transfected p16 INK4[J].Mol Carcinog,1996,16:53
  • 9Kin BN,Yamamoto H,Ikeda K,et al.Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues[J].Int J Oncol,2005,26(5):1217-1226
  • 10Iizuka I,Tangoku A,Hazama S,et al.Nm23-H1 gene as a molecular switch between the free-floating and a adherent states of gastric cancer cells[J].Cancer Lett,2001,174(1):65-71

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  • 1鲁瑶,潘瑞芹,原田英也,上妻喜腾,高岛茂树,贾振庚.VEGF、MVD和CEA与大肠癌病理学特征及预后相关性的临床研究[J].中国实用外科杂志,2005,25(6):362-364. 被引量:12
  • 2陈纲,李世拥,崔伟,陈光.低位直肠癌保肛手术后局部复发的因素分析[J].临床军医杂志,2010,38(4):503-505. 被引量:6
  • 3申东兰,胡金森,郑海霞,何艳玲,彭安,陈晓秋.外周血癌胚抗原mRNA在大肠癌组织中的表达及其临床意义[J].肿瘤防治杂志,2005,12(22):1732-1734. 被引量:3
  • 4崔天根.癌胚抗原测定在恶性肿瘤动态观察中的应用[J].职业与健康,2006,22(9):711-712. 被引量:10
  • 5Chen CC, Yang SH, Lin JK, et al. Is it reasonable to add preoper- ative serum level of CEA and CA19-9 to staging for colorecta! cancer [J]. J Surg Res, 2005,124(2) :169-174.
  • 6Kanellos I, Zacharakis E, Kanellos D, et al. Prognostic signifi- cance of CEA levels and detection of CEA rnRNA in draining ve- nous blood in patients with colorectal cancer [ J ]. J Surg Oncol, 2006,94( 1 ) :3-8.
  • 7Nozoe T, Rikimaru T, Moil E, et al, Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in eoloreetal carcinoma[J]. J Surg Oneol, 2006,94 (2) :132-137.
  • 8Meeall JL, Black RB, Rich CA, et al. The value of serum earei- noembryonie antigen in predicting recurrent disease following cura- tive of eolorectal cancer[J]. Dis Colon Rectum, 1994,37 (9) : 875-881.
  • 9Duffy MJ. Carcinoembryonic antigen as a marker for colorectal canc- er: is it clinically useful[J]. Clin Chem, 2001,47(4) :624-630.
  • 10李四光,魏光兵,王康,等.血清CEA阳性对结直肠癌临床诊断、术前评估及预后意义的研究[J].山西医学杂志,2012,41(8):1030-1032.

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