儿童感染金黄色葡萄球菌的耐药性分析

Drug Resistance Analysis of Staphylococcus Aureus Infection in Children

目的了解儿童感染的金黄色葡萄球菌（staphylococcus aureus,SA）对常用抗生素的耐药性,为临床合理用药提供参考。方法从我院2007~2009年住院患儿送检标本中分离出SA150株,采用纸片扩散法（K-B法）检测14种抗菌药物的敏感性,并运用WHONET5.3软件对药敏结果进行统计分析。结果分离出的150株SA中,甲氧西林敏感金黄色葡萄球菌（methicillin senstive suaphylococcus aureus,MSSA）77株,占51.3%;耐甲氧西林金黄色葡萄球菌（MRSA）73株,占48.7%。MRSA对几种常用抗菌药物的耐药率明显高于MSSA,差异有统计学意义（P〈0.05）;未发现耐替考拉宁和万古霉素的SA。结论儿童感染的SA对大部分抗生素敏感,但MRSA耐药较为严重,临床使用抗生素时应根据药敏试验结果审慎选择。

Objective To investigate the drug resistance of staphylococcus aureus（SA） infection to commonly used antibiotics in children for providing references to rational administration.Methods 150 strains of SA were isolated from specimens of hospitalized children during 2007 and 2009.K-B was used to detected the drug sensitivity of SA to 14 types of antibacterials,and the results were statistically analyzed by WHONET 5.3 software.Results In 150 strains of SA,77（51.3%） were（methicillin-senstive suaphylococcus aureus,MSSA）,73（48.7%） were MRSA.The drug resisitance rate of MRSA in common antibacterials was significantly higher than that of MSSA,and the difference was statistically significant（P0.05）;Resistant SA to Vancomycin and Teicoplanin was not present.Conclusion SA in children is sensitive to majority antibacterials,but the durg resistance of MRSA is more serious,and antibiotics should be carefully selected based on the results of drug sensitivity test.