青蒿和川芎挥发油的提取及包合工艺

Reasearch for the extraction of volatile oil from Qinghao and Chuanxiong and inclusion of these compunds with β-cyclodextrin

目的:考察黄蒿消炎颗粒中青蒿与川芎挥发油的提取及包合条件。方法:采用正交试验,以挥发油体积为提取工艺的指标,以包合物收得率和挥发油包合率为包合工艺的评价指标。结果:挥发油最佳提取工艺为:加10倍量的水不浸泡,提取8h;挥发油包合的最佳工艺为:采用饱和水溶液法,-βCD与挥发油比例为6∶1,在50℃下包合90min。结论:黄蒿消炎颗粒的挥发油提取及包合工艺合理可行。

OBJECTIVE To intestigate the extraction and inclusion condition of volatile oil from Qinghao（Artemisia apiacea ） and Chuanxiong （Ligusticum wallichii ） in Huanghao Xiaoyan granules. METHODS The study were carried out with orthogonal experiment. With the volume of volatile oil as the target markers, the optimum conditions were determined for extraction of the volatile oil. With the recovery rate of inclusion and the volatile oil inclusion rate as the target marker the conditions for including the oil were optimized. RESULTS The optimized extraction conditions were： the water was 10 times , the medical material should be extracted for 8 h without soaking. The optimal inclusion conditions were., applying the saturated aqueous solution method, the proportion of β-CD and oil was 6 ： 1, temperature was 50 ℃ for inclusion, and the time was 90 min. CONCLUSION The optimum conditions for extra-ction and inclusion are steady and feasible.