上海白猪腹腔镜胃转流手术两种麻醉方法的比较

To compare the effect of two anesthesia in LRYGB of Shanghai white pigs

目的比较氯胺酮麻醉和丙泊酚-异氟醚复合麻醉用于上海白猪腹腔胃转流术对血流动力学及苏醒时间的影响。方法选择健康上海白猪20只,体重45～52kg,随机分为两组,每组10只,A组采用丙泊酚-异氟醚复合麻醉,B组采用氯胺酮静脉麻醉。观察T1(气腹前5min)、T2(气腹开始后5min)、T3(气腹开始后1h)、T4(气腹结束后5min)时血流动力学变化及术毕麻醉复苏情况。结果两组在T1时MAP和HR差异无统计学意义,但在T2、T3和T4时,B组的HR和MAP均显著高于A组(P<0.05)。两组在停药至自主呼吸恢复的时间差异无统计学意义,而B组的睁眼恢复时间却较A组显著延长(P<0.05)。B组气道分泌物较多,而A组较少。结论丙泊酚-异氟醚复合麻醉和氯胺酮麻醉均可用于上海白猪的腹腔镜胃转流术,但丙泊酚-异氟醚复合麻醉血流动力学稳定,术后复苏安全迅速。

Objectives To compare the effect of the ketamine anesthesia and propofol isoflurane combined anesthesia on hemodynamics and awakening time in LRYGB of Shanghai white pigs.MethodsA total of 20 Shanghai white pigs,whose weight range 45 to 52 kg,are enrolled in this study.They are randomized divided into two groups,each group of 10 pigs.The anesthesia is maintained with the propofol are observed in both groups at four time points： time T1（5 minutes before CO2 insufflation）,T2（5 minutes after insufflation）,T3（1 hour after insufflation）,T4（5 minutes after exsufflation）.ResultsThere are no significant differences in MAP and HR between bath groups at time T1,but at time T2、T3 and T4 MAP and HR of group B are significantly higher than those of group A（P〈0.05）.There is no significant difference about the time span from withdrawal to spontaneous breathing recovery,but the eye opening recovery time of group B is much longer than that of group A（P〈0.05）.The airway secretion of group B is more than that of group A.ConclusionBoth the ketamine anesthesia and propofol isoflurane combined anesthesia can be applied to the LRYGB of Shanghai white pigs.Compared with the ketamine anesthesia,the propofol isoflurane combined anesthesia is superior to the ketamine anesthesia on hemodynamics and its recovery time is shorter.